J. W. Lockman and A. D. Hamilton.
Recent developments in the identification of chemotherapeutics for Chagas disease.
Current Medicinal Chemistry 2005, 12(8), 945-959.
DOI: 10.2174/0929867053507289
T. J. Magliery, C. G. McD. Wilson, W. Pan, D. Mischler, I. Ghosh, A. D. Hamilton, and L. Regan.
Detecting Protein-Protein Interactions with a Green Fluorescent Protein Fragment Reassembly Trap: Scope and Mechanism.
Journal of the American Chemical Society 2005, 127(1), 146-157.
DOI: 10.1021/ja046699g
H. Yin, G. Lee, G. A. Payne, J. M. Rodriguez, S. M. Sebti, and A. D. Hamilton.
Terphenyl-based helical mimetics that disrupt the p53/HDM2 interaction.
Angewandte Chemie: International Edition 2005, 44(18), 2704-2707.
DOI: 10.1002/anie.200462316
D. Carrico, M. A. Blaskovich, C. J. Bucher, S. M. Sebti, and A. D. Hamilton.
Design, synthesis, and evaluation of potent and selective benzoyleneurea-based inhibitors of protein geranylgeranyltransferase-I.
Bioorganic and Medicinal Chemistry 2005, 13(3), 677-688.
DOI: 10.1016/j.bmc.2004.10.053
R. K. Jain, L. K. Tsou, and A. D. Hamilton.
Recognition of cytochrome c by tetraphenylporphyrin-based protein surface receptors.
In K. Gloe, editor, Macrocyclic Chemistry: Current Trends and Future Perspectives, pages 267-75. Springer, 2005.
A. D. Hamilton, D. M. Tagore, and K. I. Sprinz.
Formation and recognition properties of dynamic combinatorial libraries.
In T. Schrader and A. D. Hamilton, editors, Functional Synthetic Receptors, pages 299-332. Wiley-VCH, 2005.
J. T. Woo, H. Nakagawa, A. M. Krecic, K. Nagai, A. D. Hamilton, S. M. Sebti, and P. H. Stern.
Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor (GGTI-2166) on mononuclear osteoclast formation induced by receptor activator of NF kappa B ligand (RANKL) or tumor necrosis factor-alpha (TNF-alpha).
Biochemical Pharmacology 2005, 69(1), 87-95.
DOI: 10.1016/j.bcp.2004.08.036
B. S. Zuckerbraun, J. E. Barbato, A. D. Hamilton, S. M. Sebti, and E. Tzeng.
Inhibition of geranylgeranyltransferase I decreases generation of vascular reactive oxygen species and increases vascular nitric oxide production.
Journal of Surgical Research 2005, 124(2), 256-263.
DOI: 10.1016/j.jss.2004.10.022
J. Sun, D. Wang, R. Jain, S. Paquette, T. Aya, M. A. Blaskovich, L. Baldini, D. Coppola, A. D. Hamilton, and S. M. Sebti.
Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks the binding of VEGF and PDGF to their receptors.
Oncogene 2005, 24(29), 4701-4709.
DOI: 10.1038/sj.onc.1208391
L. Nallan, K. Bauer, P. Bendale, K. Rivas, K. Yokoyama, P. R. Pendyala, D. Floyd, L. Lombardo, D. K. Williams, A. D. Hamilton, S. M. Sebti, W. T. Windsow, P. C. Weber, F. S. Buckner, D. Chakrabarti, M. H. Gelb, and W. C. Van Voorhis.
Protein farnesyltransferase inhibitors exhibit potent anti-malarial activity.
Journal of Medicinal Chemistry 2005, 48(11), 3704-3713.
DOI: 10.1021/jm0491039
H. Yin, Q. Lin, and A. D. Hamilton.
Strategies for targeting protein-protein interactions with synthetic agents.
Angewandte Chemie, International Edition 2005, 44(27), 4130-4163.
DOI: 10.1002/anie.200461786
K. Zhu, E. Gerbino, D. M. Beaupre, P. A. Mackley, C. Muro-Cacho, A. D. Hamilton, M. G. Lichtenheld, W. Dalton, M. Alsina, and S. M. Sebti.
Farnesyltransferase inhibitor R115777 (zarnestra, tipifarnib) synergizes with paclitaxel to induce apoptosis and mitotic arrest and to inhibit tumor growth of multiple myeloma cells.
Blood 2005, 105(12), 4759-4766.
DOI: 10.1182/blood-2004-11-4307
K. I. Sprinz, D. Tagore, and A. D. Hamilton.
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments.
Bioorganic and Medicinal Chemistry Letters 2005, 15(17), 3908-3911.
DOI: 10.1016/j.bmcl.2005.05.094
H. Yin, G. Lee, K. A. Sedey, J. M. Rodriguez, H. G. Wang, S. M. Sebti, and A. D. Hamilton.
Terephthalamide derivatives as mimetics of helical peptides: Disruption of the Bcl-xL/bak interaction.
Journal of the American Chemical Society 2005, 127(15), 5463-5468.
DOI: 10.1021/ja0446404
H. Yin, G. Lee, K. A. Sedey, O. Kutzki, H. S. Park, B. P. Orner, J. T. Ernst, H. G. Wang, S. M. Sebti, and A. D. Hamilton.
Terphenyl-based Bak-BH3 α-helical proteomimetics as low-molecular-weight antagonists of Bcl-xL.
Journal of the American Chemical Society 2005, 127(29), 10191-10196.
DOI: 10.1021/ja050122x
M. P. Glenn, S. Y. Chang, O. Hucke, C. L. M. J. Verlinde, K. Rivas, C. Pickeral, K. Yokoyama, F. S. Buckner, P. R. Pendyala, D. Chakrabarti, M. Gelb, W. C. Van Voorhis, S. M. Sebti, and A. D. Hamilton.
Structurally simple farnesyltransferase inhibitors arrest the growth of malaria parasites.
Angewandte Chemie, International Edition 2005, 44(31), 4903-4906.
DOI: 10.1002/anie.200500674
X. Fan, V. K. Potluri, M. C. Mcleod, R. M. Enick, A. D. Hamilton, C. B. Roberts, and E. J. Beckman.
Oxygenated hydrocarbon ionic surfactants exhibit CO2 solubility
Journal of the American Chemical Society 2005, 127(33), 11754-11762.
DOI: 10.1021/ja052037v
W. C. Guida, A. D. Hamilton, J. W. Crotty, and S. M. Sebti.
Protein farnesyltransferase: Flexible docking studies on inhibitors using computational modeling.
Journal of Computer Aided Molecular Design 2005, 19(12), 871-875.
DOI: 10.1007/s10822-005-9030-2
L. Chen, H. Yin, B. Farooqi, S. M. Sebti, A. D. Hamilton, and J. Chen.
p53 α-helix mimetics antagonize p53/MDM2 interaction and activate p53.
Molecular Cancer Therapeutics 2005, 4(6), 1019-1025.
DOI: 10.1158/1535-7163.MCT-04-0342
S. Fletcher and A. D. Hamilton.
Protein surface recognition and proteomimetics: Mimics of protein surface structure and function.
Current Opinion in Chemical Biology 2005, 9, 632-638.
DOI: 10.1016/j.cbpa.2005.10.006
J. Davis, A. Truan, and A. D. Hamilton.
Synthesis of a 2,3'-terpyridine scaffold as an α-helix mimetic.
Organic Letters 2005, 7(24), 5405-5408.
DOI: 10.1021/ol0521228
Y. Yin and A. D. Hamilton.
Protein secondary structure mimetics as modulators of protein-protein and protein-ligand interactions.
In S. Schreiber, T. Kapoor, and G. Wess, editors, First Reference of Chemical Biology. Wiley-VCH, 2005.