Photo of Martin Tomanik

Martin Tomanik

Assistant Professor

Areas of research/interest

Total synthesis of complex natural products and study of their relevant biological properties; Development of new synthetic methods that can rapidly increase molecular complexity or address long-standing issues of selectivity.

Education

B.A. in Chemistry, Dartmouth College
Ph.D. in Chemistry, Yale University
Postdoctoral Associate, The Scripps Research Institute

Selected publications

Tomanik, M.#; Qian, S.#; Yu, J.-Q., Pd(II)-Catalyzed Synthesis of Bicyclo[3.2.1] Lactones via Tandem Intramolecular β-C(sp3)–H Olefination and Lactonization of Free Carboxylic Acids. J. Am. Chem. Soc. 2022, 144, 11955-11960.

Abegg, D.; Tomanik, M.; Qiu, N.; Pechalrieu, D.; Shuster, A.; Commare, B.; Togni, A.; Herzon, S. B.; Adibekian, A., Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J. Am. Chem. Soc. 2021, 143, 20332-20342.

Tomanik, M.; Xu, Z.; Herzon, S. B., Enantioselective Synthesis of Euonyminol. J. Am. Chem. Soc. 2021, 143, 699-704.  

Tomanik, M.#; Hsu, I. T.#; Herzon, S. B. Fragment coupling reactions in total synthesis that form carbon–carbon bonds via carbanionic or free radical intermediates. Angew. Chem. Int. Ed. 2021, 60, 1116-1150.

Tomanik, M.#; Economou, C.#; Frischling, M. C.; Marks, V. A.; Mengzhao, X.; Herzon, S. B. Development of a convergent enantioselective synthetic route to (–)-myrocin G. J. Org. Chem. 2020, 85, 8952-8989.

Economou, C.; Tomanik, M.; Herzon, S. B. Synthesis of Myrocin G, the Putative Active From of the Myrocin Antitumor Antibiotics. J. Am. Chem. Soc. 2018, 140, 16058-16061.