Kent Kirshenbaum

Professor of Chemistry

Education

B.A. in Chemistry, Reed College

Ph.D. in Pharmaceutical Chemistry, University of California, San Francisco

Postdoctoral Fellow, California Institute of Technology

Areas of Research/Interest

Bioorganic Chemistry, Biomimetic Chemistry, Protein Conformation and Dynamics, Macromolecular Design

Fellowships/Honors

New York City Bio-Accelrate Competition, Awardee 2016

Golden Dozen Award for Teaching (NYU) 2011

National Science Foundation CAREER Award 2007-2012

Alzheimer's Association New Investigator Award, 2005-2007

James D.Watson Investigator Award, 2004-2006

National Institutes of Health NRSA Postdoctoral Fellowship, 2000-2002

Frank Goyan Award in Physical Chemistry at UCSF, 1998

University of California Regents Graduate Fellowship, 1994-1995

Selected Publications

Bowling, H., Bhattacharya, A., Zhang, G., Alam, D., Lebowitz, J.Z., Bohm-Levine, N., Lin, D., Singha, P., Mamcarz, M., Puckett, R., Zhou, L., Aryal, S., Sharp, K., Kirshenbaum, K., Berry-Kravis, E., Neubert, T.A., Klann, E. Altered Steady State and Activity-Dependent De Novo Protein Expression in Fragile X Syndrome. Nature Comm., 2019, 10, 1710.

Spencer, R.K., Butterfoss, G.L., Edison, J.R., Eastwood, J.R., Whitelam, S., Kirshenbaum, K., Zuckermann, R.N. Stereochemistry of Polypeptoid Chain Configurations. Biopolymers, 2019, in press.

Pankiewicz, J.E., Sanchez, S., Kirshenbaum, K., Kascsak, R.B., Kascsak, R.J., Sadowski, M.J. Anti-prion Protein Antibody 6D11 Restores Cellular Homeostasis of Prion Protein Through Disrupting Recycling Propogation of PrPSc and Targeting PrpSc for Lysosomal Degradation. Molecular Neurobiology, 2019, 56, 2073-2091.

Schneider, J.A., Craven, T.W., Kasper, A.C., Yun, C., Haugbro, M., Briggs, E.M., Svetlov V., Nudler, E., Knaut, H., Bonneau, R., Garabedian, M.J., Kirshenbaum, K., Logan, S.K. Design of Peptoid-peptide Macrocycles to Inhibit the -Catenin TCF Interaction in Prostate Cancer. Nature Comm., 2018, 9: 4396.

Andreev, K., Martynowycz, M.W., Huang, M.L., Kuzmenko, I., Bu, W., Kirshenbaum, K., Gidalevitz, D. Hydrophobic Interactions Mediate Antimicrobial Selectivity Towards Anionic Lipid Membranes. BBA-Biomembranes, 2018, 1860: 1414-1423.

Hiwatashi, N., Kraja, I., Benedict, P.A., Dion, G.R., Bing, R., Rousseau, B., Amin, M.R., Nalband, D.M., Kirshenbaum, K., Branski, R.C. Nanoparticle Delivery of RNA-based Therapeutics to Alter the Vocal Fold Tissue Response to Injury The Laryngoscope, 2018, 128, E178-E183.

Battigelli, A., Kim, J.H., Dehigaspitiya, D.C., Proulx., C., Robertson, E.J., Murray, D.J., Rad, B., Kirshenbaum, K., Zuckermann, R.N. Glycosylated Peptoid Nanosheets as a Multivalent Scaffold for Protein Recognition. ACS Nano, 2018, 12, 2455-2465. 

Kraja I.; Bing R.; Hiwatashi N.; Rousseau B.; Nalband D.; Kirshenbaum K.; Branski R.C. Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts. The Laryngoscope, 2017, 127, E231-E237.

Andreev, K.; Martynowycz, M.; Ivankin, A.; Huang, M.; Kuzmenko, I.; Meron, M.; Lin, B.; Kirshenbaum, K.; Gidalevitz, D. Cyclization Improves Membrane Permeation by Antimicrobial Peptoids. Langmuir, 2016, 32, 12905–12913.

Kraja I.; Bing R.; Hiwatashi N.; Rousseau B.; Nalband D.; Kirshenbaum K.; Branski R.C. Preliminary study of a novel transfection modality for in vivo siRNA delivery to vocal fold fibroblasts. The Laryngoscope, 2016, DOI: 10.1002/lary.26432

Wang, Y; Dehigaspitiya, D.C.; Levine, P.M.; Profit, A.A.; Haugbro, M; Imberg-Kazdan, K; Logan, S.K.; Kirshenbaum, K; Garabedian, M.J. Multivalent Peptoid Conjugates Which Overcome Enzalutamide Resistance in Prostate Cancer Cells. Cancer Research, 2016, 76, 5124-32.

Craven, T.W.; Bonneau, R.; Kirshenbaum, K. “PPII Helical Peptidomimetics Templated by Cation–π Interactions” ChemBioChem,  2016, 17: 1824-28.

Bowling, H; Bhattacharya, A; Zhang, G; Lebowitz, JZ; Alam, D; Smith, PT; Kirshenbaum, K; Neubert, TA; Vogel, C; Chao, MV; Klann, E. “BONLAC: A Combinatorial Proteomic Technique to Measure Stimulus-Induced Translational Profiles in Brain Slices” Neuropharmacology 2016 100: 76-89.

Craven, TW; Cho, MK; Traaseth, NJ; Bonneau, R; Kirshenbaum, K. “A Miniature Protein Stabilized by a Cation- Interaction Network” J. Am. Chem. Soc. 2016 138: 1543-1550.

Smith, PT; Huang, ML; Kirshenbaum, K. “Osmoprotective Polymer Additives Attenuate the Membrane Pore-forming Activity of Antimicrobial Peptoids” Biopolymers 2015 103: 227-236.

Zhang, GA; Bowling, H; Hom, N; Kirshenbaum, K; Klann, E; Chao, MV; Neubert, TA “In-Depth Quantitative Proteomic Analysis of de Novo Protein Synthesis Induced by Brain-Derived Neurotrophic Factor”  J. Proteome Res. 2014 13: 5707-5714.

Levine, PM; Garabedian, MJ; Kirshenbaum, K. “Targeting the Androgen Receptor with Steroid Conjugates” J. Med. Chem. 2014 57: 8224-8237.

Butterfoss, GL; Drew, K; Renfrew, PD; Kirshenbaum, K; Bonneau, R. “Conformational Preferences of Peptide-Peptoid Hybrid Oligomers” Biopolymers 2014 102: 369-378.

Nalband, DM; Warner, BP; Zahler, NH; Kirshenbaum, K. “Rapid Identification of Metal-Binding Peptoid Oligomers by On-Resin X-Ray Fluorescence Screening” Biopolymers 2014 102: 407-415.

Renfrew, PD; Craven, TW; Butterfoss, GL; Kirshenbaum, K; Bonneau, R. “A Rotamer Library to Enable Modeling and Design of Peptoid Foldamers” J. Am. Chem. Soc. 2014 136: 8772-8782.

Levine, PM; Craven, TW; Bonneau, R. Kirshenbaum, K. “Intrinsic Bioconjugation for Site-specific Protein PEGylation at N-terminal Serine” Chem.  Comm.  2014 50: 6909-6912.

Konca, Y. U.; Kirshenbaum, K.; Zuckermann, R. N. “Nanometer-scale siRNA Carriers Incorporating Peptidomimetic Oligomers: Physical Characterization and Biological Activity” Int. J. Nanomedicine 2014 9: 2271-2284.

Levine, P. M.; Craven, T. W.; Bonneau, R.; Kirshenbaum, K. “Semisynthesis of Peptoid–Protein Hybrids by Chemical Ligation at Serine” Org. Lett. 2014 16: 512–515.

Levine, P.M.; Craven, T.W.; Bonneau, R.; Kirshenbaum, K. “Chemoselective Fragment Condensation between Peptide and Peptidomimetic Oligomers” Org. Biomol. Chem. 2013 11: 4142-4146.

Huang, M.L.; Benson, M.A.; Shin, S.Y.; Torres, V.J.; Kirshenbaum, K. “Amphiphilic Cyclic Peptoids that Exhibit Antimicrobial Activity by Disrupting Staphylococcus aureus Membranes” Eur. J. Org. Chem. 2013: 3560-3566.

Vollrath, S.B.L.; Hu, C.; Brase, S.; Kirshenbaum, K. “Peptoid Nanotubes: An Oligomer Macrocycle that Reversibly Sequesters Water via Single-crystal-to-single-crystal Transformations” Chem. Commun. 2013 49: 2317-2319.

Drew, K.; Renfrew, P.D.; Craven, T.W.; Butterfoss, G.L; Chou, F.-C.; Lyskov, S.; Bullock, B.N.; Watkins, A.; Labonte, J.W.; Pacella, M.; Kilambi, K.P.; Leaver-Fay, A.; Kuhlman, B.; Gray; J.J.; Bradley, P.; Kirshenbaum, K.; Arora, P.S.; Das, R.; Bonneau, R. “Adding Diverse Noncanonical Backbones to Rosetta: Enabling Peptidomimetic Design” PloS One 2013 8: e67051.

Levine, P.M.; Carberry, T.; Holub, J.M.; Kirshenbaum, K. “Crafting Precise Multivalent Architectures” Med. Chem. Commun. 2013 4: 493-509.

Huang, M.; Ehre, D.; Jiang, Q.; Hu, C.; Kirshenbaum, K.; Ward, M. “Biomimetic Peptoid Oligomers as Dual-action Antifreeze Agents” Proc. Natl. Acad. Sci. USA, 2012 109: 19922-19927.

Hom, N.; Mehta, K.; Chou, T.; Foraker, A.; Brodsky, F.; Kirshenbaum, K.; Montclare, J. “Anisotropic Nanocrystal Arrays Organized on Protein Lattices Formed by Recombinant Clathrin Fragments” J. Mater. Chem. 2012 22: 23335-23339.

Butterfoss, G.L.; Yoo, B.; Jaworski,, J.N.; Chorny,, I.; Dill,, K.A.; Zuckermann, R.N.; Bonneau, R.; Kirshenbaum, K.; Voelz, V.A. “De Novo Structure Prediction and Experimental Characterization of Folded Peptoid Oligomers” Proc. Natl. Acad. Sci. USA 2012 109: 14320-14325.

Levine, P.M.; Lee, E.; Greenfield, A.; Bonneau, R.; Logan, S.K; Garabedian, M.J.; Kirshenbaum, K. “Androgen Receptor Antagonism by Divalent Ethisterone Conjugates in Castrate-resistant Prostate Cancer Cells” ACS Chem. Biol. 2012 7: 1693-1701.

Vollrath, S. B. L.; Brase, S.; Kirshenbaum, K. “Twice Tied Tight: Enforcing Conformational Order in Bicyclic Peptoid Oligomers” Chem. Sci. 2012 3: 2726-2731.

Levine, P. M.; Imberg. K; Garabedian, M. J.; Kirshenbaum, K. “Multivalent Peptidomimetic Conjugates: A Versatile Platform for Modulating Androgen Receptor Activity” J. Am. Chem. Soc. 2012 134: 6912-6915.

Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Huang, M. L.; Bonneau, R.; Wolf, C.; Kirshenbaum, K. “N-Naphthyl Peptoid Foldamers Exhibiting Atropisomerism” Org. Lett. 2012 14: 926-929.

Huang, M. L.; Shin, S. B. Y.; Benson, M. A.; Torres, V. J.; Kirshenbaum, K. “A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents” ChemMedChem 2012 7: 114-122.

Johnson, A.; Kirshenbaum, K.; McBride, A. E. "Designing a Sustainable and Stretchable 'Fox Testicle' Ice Cream", invited chapter in The Kitchen as Laboratory; editors: Vega, C.; Ubbink, J; van der Linden, E.; Columbia University Press, New York, 2012.Vollrath, S. B. L.; Brase, S.; Kirshenbaum, K. Twice Tied Tight: Enforcing Conformational Order in Bicyclic Peptoid Oligomers. (2012) In press. Chemical Science.

Levine, P. M.; Imberg. K; Garabedian, M. J.; Kirshenbaum, K. (2012) Multivalent Peptidomimetic Conjugates: A Versatile Platform for Modulating Androgen Receptor Activity.  J. Am. Chem. Soc. 134: 6912-6915.

Huang, M. L.; Shin, S. B. Y.; Benson, M. A.; Torres, V. J.; Kirshenbaum, K. (2012) A Comparison of Linear and Cyclic Peptoid Oligomers as Potent Antimicrobial Agents. ChemMedChem 7: 114-122.

Paul, B.; Butterfoss, G. L.; Boswell, M. G.; Renfrew, P. D.; Yeung, F. G.; Shah, N. H.; Wolf, C.; Bonneau, R.; Kirshenbaum, K. (2011) Peptoid Atropisomers. J. Am. Chem. Soc. 133: 10910-10919.

Maayan, G. Ward, M.; Kirshenbaum, K. (2009) Folded Biomimetic Oligomers for Enantioselective Catalysis. Proc. Natl. Acad. Sci. USA 106: 13679-13684.

Yoo, B.; Kirshenbaum, K. (2008). Peptoid Architectures: Elaboration, Actuation, and Application. Curr. Opin. Chem. Biol. 12: 714-721.

Shah, N. H.; Butterfoss, G. L.; Nguyen, K.; Yoo, B.; Bonneau, R.; Rabenstein, D. L.; Kirshenbaum, K. (2008). Oligo(N-aryl glycines): A New Twist on Structured Peptoids. J. Am. Chem. Soc. 130: 166222-16632.

Shin, S.-B.Y., Yoo, B., Todaro, L., Kirshenbaum, K. (2007). Cyclic Peptoids. J. Am. Chem. Soc. 129: 3218-3225.