Leveraging strong foundations in nano science and engineering, microfabrication, microfluidics, biosensors, clinical chemistry and artificial intelligence, the McDevitt laboratory over the past decade has pioneered development of the programmable bio-nano-chip (p-BNC) sensor platform. This mini-detection ensemble with multiplexed and multi-class (cellular, genomic, proteomic) capabilities has been customized for cancer diagnostics, cardiovascular disease, saliva-based diagnostics, infectious diseases, drugs of abuse detection, and cell imaging systems including the development of ‘pathology on a chip’. Over the past 5 years, the McDevitt laboratory has secured in-depth experience with management and execution of international prospective clinical studies for the p-BNC that resulted in the collection of unique databases and defined first-in-kind disease-wellness signatures for oral cancer and cardiac disease progression. Machine learning methods have been applied to extract accurate disease progression calculators which are now being validated clinically.

Kathleen C. Kinnally Outstanding Scientific Achievement Award, New York University 2016

Wallace H. Coulter Lectureship Award, Highest Award from AACC 2016

Selected as Member of the New York Academy of Medicine 2015

Best Clinical Research Award, 27th Annual FA Research Fund Scientific Symposium, Toronto, Canada 2015

Oral Diseases Best Original Article of the year (for “Programmable bio-nanochip-based cytologic testing of oral potentially malignant disorders in Fanconi anemia”) 2015

Scientific Founder and Chief Scientific Officer for SensoDx, LLC. 2014-Present

Nokia Sensing X Prize Finalist 2013, 2014

Outstanding New Faculty Member School of Engineering, Rice Alumni Association 2011

Stephen T. Sonis Visiting Professor Award, Brigham and Women’s Hospital 2011

Honored Alumnus Award, College of Science and Mathematics, California Polytechnic State University 2010

Popular Science Best of What's New Award in the Personal Health category 2008

Scientific Founder for LabNow, Inc. (commercial HIV immune test) 2004-2008

Gates Award Grant Recipient (HIV monitoring for use in Africa) 2004

Science Coalition Best Scientific Advances of the Year 1998

Primary inventor of “Taste Chip Technology” 1998

Best Poster Award, Boston MRS meeting 1997

Presidential Young Investigator Award, U.T. Austin 1990-1995

Exxon Education Foundation Award, U.T. Austin 1992

Grace Fellowship, Stanford University 1983-1987

Chemistry Dept. Research Award, California Polytechnic State University 1979-1982

Christodoulides, N.; McRae, M.P.; Abram, T. J.; Simmons, G.; McDevitt, J.T., Innovative Programmable Bio-Nano-Chip Digitizes Biology Using Sensors that Learn Bridging Biomarker Discovery and Clinical Implementation. Frontiers in Public Health 2017, 5, 10.3389/fpubh.2017.00110

McDevitt, J. T., The Programmable Bio-Nano-Chip: A Platform to Digitize Biology. Global Health Nexus 2016, 18 (1), 20-25b

Ebersole, J. L.; Kryscio, R. J.; Campbell, C.; Kinane, D. F.; McDevitt, J.; Christodoulides, N.; Floriano, P. N., and Miller, C. S., Salivary and Serum Adiponectin and C-Reactive Protein Levels in Acute Myocardial Infarction Related to Body Mass Index and Oral Health. Journal of Periodontal Research 2016, n/a-n/a10.1111/jre.12406.

Abram, T. J.; Floriano, P. N.; Christodoulides, N.; James, R.; Kerr, A. R.; Thornhill, M. H.; Redding, S. W.; Vigneswaran, N.; Speight, P. M.; Vick, J.; Murdoch, C.; Freeman, C.; Hegarty, A. M.; D’Apice, K.; Phelan, J. A.; Corby, P. M.; Khouly, I.; Bouquot, J.; Demian, N. M.; Weinstock, Y. E.; Rowan, S.; Yeh, C.-K.; McGuff, H. S.; Miller, F. R.; Gaur, S.; Karthikeyan, K.; Taylor, L.; Le, C.; Nguyen, M.; Talavera, H.; Raja, R.; Wong, J., and McDevitt, J. T., ‘Cytology-on-a-Chip’ Based Sensors for Monitoring of Potentially Malignant Oral Lesions. Oral Oncology 2016, 60 103-11http://dx.doi.org/10.1016/j.oraloncology.2016.07.002.

McRae, M. P.; Simmons, G.; Wong, J., and McDevitt, J. T., Programmable Bio-Nanochip Platform: A Point-of-Care Biosensor System with the Capacity to Learn. Accounts of Chemical Research 2016, 49 (7), 1359-6810.1021/acs.accounts.6b00112.

King, K. R.; Grazette, L. P.; Paltoo, D. N.; McDevitt, J. T.; Sia, S. K.; Barrett, P. M.; Apple, F. S.; Gurbel, P. A.; Weissleder, R.; Leeds, H.; Iturriaga, E. J.; Rao, A. K.; Adhikari, B.; Desvigne-Nickens, P.; Galis, Z. S., and Libby, P., Point-of-Care Technologies for Precision Cardiovascular Care and Clinical Research : National Heart, Lung, and Blood Institute Working Group. JACC: Basic to Translational Science 2016, 1 (1-2), 73-86

McRae, M.; Simmons, G.; McDevitt, J., Challenges and Opportunities for Translating Medical Microdevices: Insights from the Programmable Bio-Nano-Chip. Bioanalysis 2016, 8 (9), 905-19.

McRae, M.; Bozkurt, B.; Ballantyne, C.; Sanchez, X.; Christodoulides, N.; Simmons, G.; Nambi, V.; Misra, A.; Miller, C.; Ebersole, J.; Campbell, C.; McDevitt, J., Cardiac Scorecard: A Diagnostic Multivariate Index Assay System for Predicting a Spectrum of Cardiovascular Disease. Expert Systems with Applications 2016, 54, 136-147.10.1016/j.eswa.2016.01.029.

Speight, P.; Abram, T.; Floriano, P.; James, R.; Vick, J.; Thornhill, M.; Murdoch, C.; Freeman, C.; Hegarty, A.; D'Apice, K.; Kerr, A.; Phelan, J.; Corby, P.; Khouly, I.; Vigneswaran, N.; Bouquot, J.; Demian, N.; Weinstock, Y.; Redding, S.; Rowan, S.; Yeh, C.; McGuff, H.; Miller, F.; McDevitt, J., Inter-Observer Agreement in Dysplasia Grading: Toward an Enhanced Gold Standard for Clinical Pathology Trials. Oral Surgery Oral Medicine Oral Pathology Oral Radiology 2015, 120 (4), 474-482.10.1016/j.oooo.2015.05.023.

Shadfan, B.; Simmons, A.; Simmons, G.; Ho, A.; Wong, J.; Lu, K.; Bast, R.; McDevitt, J., A Multiplexable, Microfluidic Platform for the Rapid Quantitation of a Biomarker Panel for Early Ovarian Cancer Detection at the Point-of-Care. Cancer Prevention Research 2015, 8 (1), 42-53.10.1158/1940-6207.CAPR-14-0248.

McRae, M. P.; Simmons, G. W.; Wong, J.; Shadfan, B.; Gopalkrishnan, S.; Christodoulides, N.; McDevitt, J. T., Programmable Bio-Nano-Chip System: A Flexible Point-of-Care Platform for Bioscience and Clinical Measurements. Lab on a Chip 2015, 15 (20), 4020-4031.10.1039/c5lc00636h.

McDevitt, J.; McRae, M.; Simmons, G.; Christodoulides, N., Programmable Bio-Nano-Chip System: A Flexible Diagnostic Platform That Learns. Journal of Biosensors & Bioelectronics 2015, 06 (02), 1-2.10.4172/2155-6210.1000e137.

Kulla, E.; Chou, J.; Simmons, G. W.; Wong, J.; McRae, M. P.; Patel, R.; Floriano, P. N.; Christodoulides, N.; Leach, R. J.; Thompson, I. M.; McDevitt, J. T., Enhancement of Performance in Porous Bead-Based Microchip Sensors: Effects of Chip Geometry on Bio-Agent Capture. Rsc Advances 2015, 5 (60), 48194-48206.10.1039/c5ra07910a.

Floriano, P.; Abram, T.; Taylor, L.; Le, C.; Talavera, H.; Nguyen, M.; Raja, R.; Gillenwater, A.; McDevitt, J.; Vigneswaran, N., Programmable Bio-Nano-Chip Based Cytologic Testing of Oral Potentially Malignant Disorders in Fanconi Anemia. Oral Disorders 2015.10.1111/odi.12321.

Christodoulides, N.; De La Garza, R.; Simmons, G.; McRae, M.; Wong, J.; Newton, T.; Smith, R.; Mahoney, J.; Hohenstein, J.; Gomez, S.; Floriano, P.; Talavera, H.; Sloan, D.; Moody, D.; Andrenyak, D.; Kosten, T.; Haque, A.; McDevitt, J., Application of Programmable Bio-Nano-Chip System for the Quantitative Detection of Drugs of Abuse in Oral Fluids. Drug and Alcohol Dependence 2015, 153,306-313.10.1016/j.drugalcdep.2015.04.026.

Christodoulides, N.; De La Garza, R.; Simmons, G.; McRae, M.; Wong, J.; Newton, T.; Kosten, T.; Haque, A.; Abdel-Meguid, S. S.; McDevitt, J., Next Generation Programmable Bio-Nano-Chip System for on-Site Quantitative Drug Detection in Oral Fluids. Journal of Drug Abuse 2015, 1 (15), 1-6.