Jin Kim Montclare

Yale University, Class of 2003 MS, PhD, Bioorganic Chemistry Fordham University, Class of 1997 BS, Chemistry

protein engineering, chemical biology, biomaterials self-assembly, artificial proteins biocatalyis

2015 Agnes Fay Morgan Research Award from Iota Sigma Pi, National Honor Society for Women in Chemistry 2014 Distinguished Award for Excellence, Dedication to Invention, Innovation and Entrepreneurship 2014 Executive Leadership in Academic Technology and Engineering Fellow 2013 NSF I-Corps 2009 Young Observer Fellowship (declined) 2008 ACS PROGRESS/Dreyfus Lectureship 2008 Dreyfus Special Grants Program Award 2007 AFOSR Young Investigator Award 2006 Wechsler Award for Excellence 2006 Othmer Junior Fellow, Othmer Institute 2003-2005 National Institute of Health Postdoctoral Fellowship 2001 T. F. Cooke Teaching Award for Organic Chemistry; Yale University 1997-2000 National Science Foundation Graduate Research Fellowship 1997-2000 Pfizer Fellowship

AUTHORED + EDITED BOOKS

Joseph A. Frezzo & Jin K. Montclare, Natural Composite Systems for Bioinspired Materials. In Protein-based Engineered Nanostructures (2015) Edited by T. Z. Groves and A. L. Cortajarena. In press.

Haresh T. More, Ching-Yao Yang & Jin K. Montclare, Post-Translational Modification of Proteins Incorporating Non-natural Amino Acids. In Functional Polymers by Post-Polymerization Modification: Concepts, Practical Guidelines and Applications (2012) Edited by H. A. Klok and P. Theato.

Peter James Baker, Jennifer S. Haghpanah & Jin K. Montclare Elastin-basted Protein Polymers. In Polymer Biocatalysts and Biomaterials II (2008) Edited by H. N. Cheng and R. A. Gross. Chapter 3.

Peter J. Baker & Jin K. Montclare, Biotransformations using Cutinase. In Green Polymer Chemistry: Biocatalysis and Biomaterials (2010) Edited by H. N. Cheng and R. A. Gross. 1043, 141-158.


JOURNAL ARTICLES

Jasmin Hume, Raymond Chen,+ Rudy Jacquet, Michael Yang+ & Jin K. Montclare. Tunable Conformation Dependent Protein Gold Nanoparticle Nanocomposites. Biomacromolecules (2015) 16, 1706-1713. DOI: 10.1021/acs.biomac.5b00098

Joseph A. Frezzo & Jin K. Montclare. Exploring the potential of engineered coiled-coil protein microfibers in drug delivery. Therapeutic Delivery (2015) 6, 643-646.

Haresh T. More, Kevin S. Zhang,+ Nikita Srivastiva, Joseph A. Frezzo & Jin K. Montclare. Influence of Fluorination on Protein Engineered Coiled-coil Fibers. Biomacromolecules (2015) 16, 1210–1217. DOI: 10.1021/bm5019062

Jasmin Hume, Jennifer Sun,+ Rudy Jacquet, P. Douglas Renfrew, Jesse A. Martin, Richard Bonneau, M. Lane Gilchrist & Jin K. Montclare. Engineered Coiled-Coil Protein Microfibers. Biomacromolecules (2014) 15, 3503-3510. DOI: 10.1021/bm5004948

Ching-Yao Yang, P. Douglas Renfrew, Andrew J. Olsen, Michelle Zhang+, Carlo Yuvienco, Richard Bonneau, Jin K. Montclare. Improved Stability and Half-life of Fluorinated Phosphotriesterase using Rosetta. ChemBioChem (2014) 15, 1761-1764.

Haresh T. More, Joseph A. Frezzo, Jisen Dai, Seiichi Yamano, Jin K. Montclare. Efficient Gene Delivery from Supercharged Coiled-coil Protein and Cationic Lipid Nanocomplexes. Biomaterials (2014) 35, 7188-7193.

Seiichi Yamano, Jisen Dai, Shigeru Hanatani, Ken Haku, Takuto Yamanaka, Mika Ishioka, Tadahiro Takayama, Carlo Yuvienco, Sachin Khapli, Amr M. Moursi, Jin K. Montclare. Long-term efficient gene delivery using polyethylenimine with modified Tat peptide. Biomaterials (2014) 34, 1705-1715.

Jennifer S. Haghpanah, Raymond Tu, Sandra Da Silva, Deng Yan, Silvana Mueller, Christoph Weder, E. Johan Foster, Iulia Sacui, Jeffery W. Gilman, Jin K. Montclare. Bionanocomposites: Differential Effects of Cellulose Nanocrystals on Protein Diblock Copoloymers. Biomacromolecules (2013) 14, 4360-4367.

Daniel Yoo, Nick Tovar, Ryo Jimbo, Charles Marin, Rodolfo Anchieta, Lucas Machado, Jin Montclare, Fernando Guastaldi, Malvin Janal & Paulo Coelho, Increased Osseointegration Effect of BMP-2 on Dental Implants: An In Vivo Study. Clinical Implant Dentistry and Related Research. (2013) doi: 10.1002/jbm.a.34862

Herbert Lannon, Jennifer S. Haghpanah, Jin K. Montclare, Eric Vanden-Eijnden & Jasna Brujic. Force-clamp experiments reveal the free energy profile and diffusion coefficient of the collapse of proteins. Phys, Rev. Lett. (2013) 110, 128301-6. doi:10.1103/PhysRevLett.110.128301

Nancy Hom, Kinjal R. Mehta, Tsengming Chou, Amy B. Foraker, Frances M. Brodsky, Kent Kirshenbaum & Jin K. Montclare. Anisotropic nanocrystal arrays organized on protein lattices formed by recombinant clathrin fragments. J. Mat. Chem. (2012) 22, 23335-23339.

Carlo Yuvienco, Haresh T. More, Jennifer S. Haghpanah, Raymond S. Tu & Jin K. Montclare, Modulating Supramolecular Assemblies and Mechanical Properties of Engineered Protein Materials by Fluorinated Amino Acids. Biomacromolecules. (2012) 13, 2273-2278.

Susheel K. Gunasekar, Luona Anjia, Hiroshi Matsui & Jin K. Montclare. Effects of Divalent Metals on Nanoscopic Fiber Formation and Small Molecule Recognition of Helical Proteins. Adv. Funct. Mat. (2012) 22, 2154-2159.

Peter J. Baker, Yan M. Chan, Moritz Hertel & Jin K. Montclare. Characterization and Identification of Protein Partners of Fn3 Domain in FnTm2. Protein Expression and Purification (2012) 81, 42-48.

Peter J. Baker, Christopher S. Poultney, Zhiqiang Liu, Richard Gross & Jin K. Montclare. Identification and Comparison of Cutinases for Synthetic Polyester Degradation. Applied Microbiology and Biotechnology (2012) 93, 229-240.

Min Dai, jennifer S. Haghpanah, Navjot Singh, Eric W. Roth, Alice Liang, Raymond S. Tu & Jin K. Montclare, Artificial Protein Block Polymer Libraries Bearing Two SADs: Effects of Elastin Domain Repeats. Biomacromolecules. (2011) 12, 4240-4246.

Kinjal R. Mehta, Ching-Yao Yang & Jin K. Montclare, Modulating substrate specificity of histone acetyltransferase with unnatural amino acids. Mol. BioSyst. (2011) 7, 3050-3055

Peter J. Baker & Jin K. Montclare, Enhanced refoldability and thermoactivity of fluorinated phosphotriesterase. Chembiochem, (2011) 12, 1845-1848.

Seiichi Yamano, Jisen Dai, Carlo Yuvienco, Sachin Khapli, Amr M. Moursi & Jin K. Montclare. Modified Tat peptide with lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis. J. Contr. Rel. (2011) 152, 278-285.

Jennifer S. Haghpanah, Carlo Yuvienco, Eric W. Roth, Alice Liang, Raymond S. Tu & Jin K. Montclare, Supramolecular Assembly and Small Molecule Recognition by Genetically Engineered Protein Block Polymers Composed of Two SADs. Mol. BioSys. (2010) 6, 1662-1667.

Kinjal R. Mehta, Yan M. Chan+, Man X. Lee+, Ching Yao Yang, Natalya Voloshchuk & Jin K. Montclare. Mutagenesis of tGCN5 core region reveals two critical surface residues F90 and R140. Biochem. Biophys. Res. Comm. (2010) 400, 363-368.

Natalya Voloshchuk & Jin K. Montclare, Incorporation of unnatural amino acids for synthetic biology. Mol. BioSys. (2010) 6, 65-80.

Jennifer S. Haghpanah, Carlo Yuvienco, Deniz E. Civay, Hanna Barra, Peter J. Baker, Sachin Khapli, Natalya Voloshchuk, Susheel K. Gunasekar, Murugappan Muthukumar & Jin K. Montclare, Artificial protein block copolymers comprised of two self-assembling domains. ChemBioChem. (2009) 10, 2733-2735. *Highlighted in Futurity* http://futurity.org/

Zhiqiang Liu, Yuying Gosser, Peter James Baker, Yaniv Ravee, Ziying Lu, Girum Alemu, Huiguang Li, Glenn L. Butterfoss, Xiang-Peng Kong, Richard Gross & Jin K. Montclare, Structural and functional studies of A. oryzae cutinase: Enhanced thermostability and hydrolytic activity of synthetic ester and polyester degradation. J. Am. Chem Soc. (2009) 131, 15711-15716.

Susheel K. Gunasekar, Mukta Asnani, Chandani Limbad, Jennifer S. Haghpanah, Wendy Hom, Hanna Barra, Soumya Nanda & Jin K. Montclare, N-terminal aliphatic residues dictate the structure, stability and assembly of the coiled-coil region of COMP. Biochemistry. (2009) 48, 8559–8567.

Natalya Voloshchuk, Anita Yuhua Zhu, David Snydacker & Jin K. Montclare, Positional effects of monofluorinated phenylalanines on histone acetyltransferase stability and activity. Bioorg. Med. Chem. Lett. (2009) 19, 5449-5451.

Sachin Khapli, Jin R. Kim, Jin K. Montclare, Rastislav Levicky, Mauricio Porfiri and Stavroula Sofou. Frozen cyclohexane-in-water emulsion as a sacrificial template for the synthesis of multilayered polyelectrolyte microcapsules. Langmuir, (2009) 17, 9728-9733.

Jin K. Montclare*, Soojin Son*, Ginevra Clark, Krishna Kumar & David A. Tirrell, Biosynthesis of stable dimeric coiled-coils bearing (2S, 4R)-5’,5’,5’-trifluoroleucine and (2S, 4S)-5’,5’,5’-trifluoroleucine. ChemBioChem (2009) 10, 84-86. * these authors contributed equally

Susheel K. Gunasekar, Jennifer S. Haghpanah & Jin K. Montclare, Assembly of bioinspired protein fibers. Polymers for Advanced Technology. (2008) 19, 454-468.

Natalya Voloshchuk, Man Xia Lee, Wan Wen Zhu, Ismet Caglar Tanrikulu & Jin K. Montclare, Fluorinated chloramphenicol acetyltransferase thermostability and activity profile: improved thermostability by a single-isoleucine mutant. Bioorganic Medicinal Chemistry Letters (2007) 17, 5907-5911.

Tatyana Panchenko, Wan Wen Zhu & Jin K. Montclare, Influence of global fluorination on chloramphenicol acetyltransferase activity and stability. Biotechnology and Bioengineering (2006) 94, 921-930.

Jin K. Montclare, Soojin Son, Ginevra Clark, Krishna Kumar & David A. Tirrell, Biosynthesis of stable dimeric coiled-coils bearing (2S, 4R)-5’,5’,5’-trifluoroleucine and (2S, 4S)-5’,5’,5’-trifluoroleucine. ChemBioChem (2009) 10, 84-86.

Jin K. Montclare & David A. Tirrell, Evolving proteins of novel composition. Angewandte Chemie International Edition (2006) 45, 4518-4521.

Jin K. Montclare & Alanna Schepartz, Miniature homeodomains: High specificity without an N-terminal arm. J. Am. Chem. Soc. (2003) 125, 3416-3417.

Jin K. Montclare, Leslie S. Sloan & A. Schepartz, Electrostatic control of half-site spacing preferences by the cyclic AMP Response Element Binding Protein: Selectivity at the expense of affinity. Nucleic Acids Res. (2001) 29, 3311-3319.


OTHER PUBLICATIONS

Priya Chacko, Sarah Appelbaum, Heejoo Kim, Jinhui Zhao & Jin K. Montclare. Integrating Technology in STEM Education. J. Tech. Sci. Ed. (2015) 5, 5-14.

Heejoo Kim, Priya Chacko, Jinhui Zhao & Jin K. Montclare. Using Touch-Screen Technology, Apps, and Blogs To Engage and Sustain High School Students’ Interest in Chemistry Topics. J. Chem. Ed. (2014) 91, 1818-1822. doi: 10.1021/ed500234z.

Maurica S. Lewis, Jinhui Zhao & Jin K. Montclare. Development and Implementation of High School Chemistry Modules using Touch-Screen Technologies. J. Chem. Ed. (2012) 89, 1012-1018.

Robert Lorenzini, Maurica S. Lewis & Jin K. Montclare. College-Mentored Polymer/Materials Science Modules for Middle and High School Students. J. Chem. Ed. (2011) 88, 1105-1108.

Yan M. Chan, Wendy Hom & Jin K. Montclare. Mentored Chem-Bio Technology Lab to Promote Early Interest in Science. J. Chem. Ed. (2011) 88, 751-754.