Aneel K. Aggarwal

Education

Ph.D. Kings College, University of London, England, UK

Areas of Research/Interest

Biophysics; DNA-binding proteins.

Escalante CR, Nistal-Villan E, Shen L, Garsia-Sastre A, Aggarwal AK. Structure of IRF-3 bound to the PRDIII-I regulatory element of the human interferon-beta enhancer. Mol Cell 2007 Jun; 26(5):703-16.

Lone S, Townson SA, Uljon SN, Johnson RE, Brahma A, Nair DT, Prakash S, Prakash L, Aggarwal AK. Human DNA polymerase kappa encircles DNA: implications for mismatch extension and lesion bypass. Mol Cell 2007 Feb; 25(4):601-14.

Vanamee ES, Berriman J, Aggarwal AK. An EM view of the FokI synaptic complex by single particle analysis. J Mol Biol 2007 Jul; 370(2):207-12.

Nair DT, Johnson RE, Prakash L, Prakash S, Aggarwal AK. Rev1 employs a novel mechanism of DNA synthesis using a protein template. Science 2005 Sep; 309(5744):2219-22.

Nair DT, Johnson RE, Prakash S, Prakash L, Aggarwal AK. Replication by human DNA polymerase-iota occurs by Hoogsteen base-pairing. Nature 2004 Jul; 430(6997):377-80.

Edwards TA, Pyle SE, Wharton RP, Aggarwal AK. Structure of Pumilio reveals similarity between RNA and peptide binding motifs. Cell 2001 Apr; 105(2):281-9.

Scully KM, Jacobson EM, Jepsen K, Lunyak V, Viadiu H, Carriere C, Rose DW, Hooshmand F, Aggarwal AK, Rosenfeld MG. Allosteric effects of Pit-1 DNA sites on long-term repression in cell type specification. Science 2000 Nov; 290(5494):1127-31.

Passner J, Ryoo HD, Shen L, Mann RS, Aggarwal A. Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature 1999 Feb 25; 397(6721):714-9.