Alisha Jones

Structural dynamics and protein binding of lncRNAs and their influence on conformational changes to regulate gene expression.

Therapeutically targeting structural conformations of lncRNAs implicated in disease

*Jones, A.N., *Tikhaia, E., Mourao, A., Sattler, M. Structural effects of m6A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1. NAR. 2022. 50(4):2350-2362

Jones, A.N., Grass, C., Meininger, I., Geerlof, A., Zarnack, K., Krappmann, D., Sattler, M., Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1 in T cells. Science Advances. 2022. 8(31):1-14

Calonaci, N., Jones, A.N., Cuturello, F., Sattler, M., Bussi, G. Machine learning a model for RNA structure prediction. NAR Genomics and Bioinformatics. 2020. 2(4): lqaa090

Jones, A.N., Pisignano, G., Pavelitz, T., White, J., Kinisu, M., Forino, M., Varani, G., An evolutionarily-conserved RNA structure in the functional core of the lncRNA Cyrano. RNA. 2020. 26(9):1234-1246

*Shortridge, M.D., *Wille, P.T., *Jones, A.N., Davidson, A., Bogdanovic, J., Arts, E., Karn, J., Robinson, J.A., and Varani, G. An ultra-high affinity inhibitor of HIV-1 TAR reveals the RNA structure recognized by P-TEFb. NAR. 2018. 3(47):1523-1531