The Hamilton Group published a piece in Organic Letters entitled, "Heterofunctionalized Cavitands by Macrocyclization of Sequence-Defined Foldamers" which was selected as an ACS Editor's Choice paper. The authors are postdoctoral fellow Joseph W. Meisel, X-Ray Crystallographer Chunhua T. Hu and NYU President and Professor of Chemistry Andrew D. Hamilton.
Abstract: Macrocyclic hosts have long been the workhorses of molecular recognition. Despite the widespread use of container-shaped molecules as synthetic receptors, an efficient preparation of cavitands bearing multiple functional groups has not been realized. This Letter describes a new cavitand derived from a sequence-defined oligoamide foldamer scaffold. A solid-phase synthesis approach is reported, which enables the display of multiple chemically diverse functional groups on the cavitand rim.
To read the complete article in Organic Letters, click here.
This work was supported by the National Institutes of Health and the National Science Foundation, through the NYU Materials Research Science and Engineering Conter and other grants.