Shyam Sathyamoorthi, from the University of Kansas, will deliver a seminar entitled, "Tethered Alkene Functionalization Technology for Complex Molecule Assembly." Hosted by Marvin Parasram.
For more information about Shyam Sathyamoorthi, click here.
Abstract: Advances in tethered olefin functionalization technology will greatly aid in the precise installation of alcohols and amines and in the efficient construction of stereochemical arrays. In such reactions, a nucleophilic auxiliary (“the tether”) is appended to ubiquitous functional groups, usually alcohols or amines, followed by a cyclization event. Because of geometric constraints on the transition states of intramolecular reactions, such cyclizations generally proceed with predictable regioselectivity and high diastereocontrol. In this presentation, I will describe my laboratory’s development of several classes of tethered olefin functionalization reactions and their applications to complex antibiotic synthesis.