Christo Sevov, from The Ohio State University, will deliver a seminar entitled, "Mediator-Assisted Strategies for Electrocatalytic C–C and C–N Coupling Reactions." Hosted by Tianning Diao.
For more inofrmation about Christo Sevov, click here.
Abstract: The seminar will describe our efforts towards the development of scalable, mild, and general electrosynthetic methodologies for C–C and C–N coupling reactions. These electrosynthetic methodologies are possible because of a synergy between conventional transition metal catalysts for cross coupling and redox-active mediators developed by the battery community. It will be shown that yields from electrocatalytic reactions are dramatically improved with the incorporation of co-catalytic quantities of soluble battery compounds and other redox mediators that serve to assist in electron transfer with the coupling catalyst, protect the coupling catalyst from over-oxidation/reduction and degradation, or promote in the formation of highly-reactive intermediates.
A particular focus will be placed on the discussion of a previously-unknown pathway for electrochemically-generating highly-reactive Ni(0) complexes at mild potentials through a choreographed series of ligand exchange reactions. We leverage this unique mechanism towards coupling of 3° alkyl bromides, aryl chlorides, aryl triflates, vinyl triflates, and alkyl-aryl combinations therein that represent previously-unknown reaction. This general mechanism is applied to a range of new transformations.