Cathleen Crudden, of Queen's University & the Institute of Transformative Bio-Molecules, will deliver a seminar entitled, "Metal catalysts, clusters and surfaces: Catalytic preparation of chiral bio-molecules and the chemistry of carbon-based monolayers." Hosted by Marvin Parasram.
For more information about Cathleen Crudden, click here.
Zoom Link:
https://nyu.zoom.us/j/95668157805?pwd=d1MrakwvN2QwNVBzQmFLU1NjS2szdz09
Abstract: The use of N-heterocyclic carbenes to modify homogeneous metal catalysts is widespread since the high metal–NHC bond strength renders high oxidative and chemical stability to NHC–ligated metal complexes. Despite this fact, the use of NHCs to modify metal surfaces is virtually unprecedented.
We will describe the first example of the synthesis of gold surfaces, including Au(111), Au nanoparticles and Au nanoclusters. Films prepared by the deposition of NHCs show molecular ordering on the surface and remarkable stability. The impact of this stability on the chemistry of nanoclusters will also be discussed.
We will also describe advances in organoboron chemistry that have dramatically broadened the applicability of this versatile element. In particular, we will describe its application in the preparation of complex chiral molecules of interest to the pharmaceutical industry and the ability to cross-couple seemingly identical boron substituents with different aryliodides. The development of novel electrophiles for Suzuki-Miyaura cross coupling chemistry in the preparation of bioactive molecules will also be presented as will our developments in the use of sulfones as electrophiles for cross-coupling reactions.
