Buddhadeb Chattopadhyay, Division of Molecular Synthesis & Drug Discovery at the Centre of Biomedical Research (CBMR) in India, will deliver a seminar entitled, "Catalysis for Remote C–H Bond Borylation and Denitrogenative Annulation." Hosted by Marvin Parasram.
For more information about Buddhadeb Chattopadhyay, click here.
Zoom link: https://nyu.zoom.us/j/95385309546?pwd=alJaeXBEKzExZExTM2VJWDB0dlpKUT09
Abstract: The direct C–H bond functionalization using transition metal catalysts is one of the key emergent methods that is currently drawing remarkable attention owing to the rapidly expanding abundant chemical feedstocks to achieve higher-value materials. Among them, the C–H bond borylation is a unique functionalization reaction due to the versatile synthetic transformation of the C–B bond and the key role of the organoboron reagents in the construction of natural products, pharmaceuticals, fine chemicals and boron-bearing small drug molecules. In this context, among various transition metal-mediated C–H borylation, use of iridium-based catalytic system is the major contributing factor compared to other transition metals. We have been working in the area of C–H bond activation and borylation chemistry, where site selectivity is primarily controlled by the noncovalent interactions between the ligand and the substrate. In this talk, I will demonstrate that noncovalent interaction to be a feasible approach for the iridium-catalyzed remote C–H bond activation and borylation of arenes. Moreover, I will show some current discoveries of metalloradical activation approaches for the denitrogenative annulation to make nitrogen heterocycles.
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