Angela Casini, Chair of Medicinal and Bioinorganic Chemisry and Liesel Beckmann Distinguished Professor at the Technical University of Munich, will deliver a virtual seminar entitled, "Bioinorganic chemistry as an enabling technology." Hosted by Daniela Buccella.
Zoom Link: https://nyu.zoom.us/j/95860394467?pwd=SWFoNG1WMTJpRVZSeElieitrcG0ydz09
For more information about Amgela Casini, click here.
Abstract: The purpose of this seminar is to provide evidence of how bioinorganic chemistry knowledge can be applied to drive change in technologies in diverse areas of chemical science.
As a first example, the case of gold-based catalysts will be discussed since they offer the opportunity of modulating bio-processes through reactions that are complementary to enzymes, and have emerged as promising tools for bio-orthogonal transformations, endowed with excellent reactivity and selectivity, compatibility within aqueous reaction medium, fast kinetics of ligand exchange reactions and mild reaction conditions.[1] Thus, this lecture will summarize recent findings from our group on Au(III)- catalyzed reductive elimination in aqueous media, providing the proof-of-concept for the use of organogold compounds – cyclometalated Au(III) C^N complexes - for the efficient modification of proteins through C–S cross coupling.[2] Furthermore, the obtained mechanistic insights have allowed to extend the cross-coupling concept to other substrates, to enable C–P and C–C bond formation under mild conditions.[3] These results could be relevant to the development of proteomic profiling of cysteine residues and of their oxidation states, as well as for the design of catalysts in different cross-coupling processes in aqueous environment. Moreover, a second example on the application of bioconjugated photoactivable Ru(II) complexes to implement mass spectrometry imaging (MSI) will be included. Specifically, the proof-of-concept on a novel laser desorption ionization (LDI)-MSI strategy using photocleavable Ru(II) polypyridine complexes as mass-tags for imaging of integrins αvβ 3 in human cancer tissues (Figure 1) will be presented.[4]