This seminar was rescheduled from April 21, 2020.
Please note that this is a Monday.
Song Lin, the Howard Milstein Faculty Fellow and Assistant Professor of Chemistry and Chemical Biology at Cornell University, will deliver a seminar entitlted, "Amping Up Organic Synthesis with Electricity: Electrocatalytic Difunctionalization of Alkenes." Hosted by Tianning Diao.
Zoom Link: https://nyu.zoom.us/j/99648790716?pwd=RG4vaUF5amp2T1R6UUhPcW1iN3dtZz09
For more information about Song Lin, click here.
Abstract: Oxidation and reduction reactions are among the most important and frequently executed processes in organic synthesis. However, our ability to manipulate the oxidation states of functional groups in complex settings with high efficiency, precision, and minimal waste remains in a largely nascent stage. Owing to its many distinct characteristics, electrochemistry represents an attractive approach to meet the prevailing trends in organic synthesis. In particular, electrocatalysis—a process that integrates electrochemistry and small molecule catalysis—has the potential to substantially improve the scope of synthetic electrochemistry and provide a wide range of useful transformations. Despite its attractive attributes and extensive applications in energy-related fields, electrocatalysis has been used only sparingly in synthetic organic chemistry. Thus, there exists a clear impetus for inventing new catalytic strategies to improve the scope of synthetic electrochemistry and provide new platforms for reaction discovery and synthetic innovations. Toward this end, we developed a new catalytic approach that combines electrochemistry and redox-metal catalysis for the oxidative difunctionalization of alkenes to access a diverse array of vicinally functionalized structures. This presentation will detail our design principle underpinning the development of electrocatalytic alkene diazidation with a particular emphasis on enantioselective catalysis.
References:
1. Fu, N.; Sauer, G. S.; Saha, A.; Loo, A; Lin, S. Science 2017, 357, 575-579.
2. Ye, K.; Pombar, G.; Fu, N.; Sauer, G. S.; Keresztes, I.; Lin, S. J. Am. Chem. Soc. 2018, 140, 2438-2441.
3. Fu, N.; Sauer, G. S.; Lin, S. J. Am. Chem. Soc. 2017, 139, 15548-15553.
4. Sauer, G. S.; Lin, S. ACS Catal. 2018, 8, 5175-5187.