Andrew McNally, of Colorado State University, will deliver a seminar entitled, "Selective Functionalization of Pyridines, Diazine and Pharmaceuticals via Heterocyclic Phosphonium Salts." Hosted by Tianning Diao.
For more information about Andrew McNally, click here.
Abstract: Selective methods that can functionalize electron-deficient heterocycles are in great demand due to their prevalence in biologically active compounds. Pyridines and diazines, in particular, are widespread components of pharmaceutical compounds yet methods to transform these motifs into valuable derivatives are still greatly sought after. We will present a selection of catalytic and non-catalytic methods using phosphorus intermediates that enable multiple new bond-constructions on these heterocycles. A particular emphasis will be placed on phosphorus ligand-coupling reactions that represent an alternative means to form C–C and C-Heteroatom bonds.