Jiaoyang Jiang, from the University of Wisconsin's School of Pharmacy, will deliver a seminar entitled, "Specificity, Function and Regulation of Protein O-GlcNAc Modification." Hosted by Lara Mahal.
For information about the speaker, click here.
Abstract: The N-acetylglucosamine (O-GlcNAc) modification is an essential glycosylation that has been identified on over 1,000 proteins. It dynamically modulates protein functions and regulates numerous biological processes in physiology and disease. O-GlcNAc modification is added by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA). Despite recent progress, challenges remain to decipher the biological roles of O-GlcNAc modification and its regulation by OGT and OGA on a broad range of substrates that lack an apparent sequence motif. In this talk, I will present our recently developed structural biology and chemical biology approaches to start revealing the specificity, function and regulation of O-GlcNAc modification.