Hans Renata, of Scripps Research Institute, will deliver a seminar entitled, "Biocatalytic C–H Oxidation as an Enabling Tool for Complex Molecule Synthesis." Hosted by Tianning Diao.
For more information about Hans Renata, click here.
Abstract: Direct oxidation and functionalization of C–H bonds, though ubiquitous in
Nature’s biosynthetic machinery, have only recently gained traction as a
viable strategy in chemical synthesis. Despite rapid advances in the past
decade, contemporary chemical methods for C–H oxidation still face
significant challenges in achieving useful levels of selectivity on complex
scaffolds. In contrast, the oxidative enzymes that have evolved to perform
these transformations are capable of achieving unprecedented levels of
selectivity. However, the applications of these catalysts in organic synthesis
have remained largely overlooked. This talk will describe our recent efforts
in developing a new design language in chemical synthesis that centers on
the application of biocatalytic C–H functionalization logic. Case studies will
focus on the use of this platform in the chemoenzymatic syntheses of
complex natural products.