Research in our lab utilizes expertise in organic chemistry to develop synthetic inhibitors of protein-protein and protein-nucleic acids interactions. These interactions are difficult targets for typical small molecule ligands. We are using a rational design approach to prepare synthetic scaffolds that will potentially offer highly specific reagents for biological studies.

email: arora@nyu.edu

Professor Bar-Sagi currently holds the title of Vice President of Research at NYU school of  Medicine. The research in our laboratory focuses a signaling axis that is deregulated in more than 30% of human cancers due to the mutational activation of the GTP-binding protein Ras. We are interested in defining the contribution of specific molecular perturbations in this signaling axis to cancer initiation and progression with the ultimate goal of utilizing this information for the development of novel diagnostic and therapeutic strategies.

email:dafna.bar-sagi@nyumc.org

My lab is focused on a number of computational biology problems that, if solved, would remove key bottlenecks in biology and systems biology. We focus on two main categories of computational biology: learning networks from functional genomics data and predicting and modeling protein structure. In both areas I have played key roles in solving unsolved problems and achieving critical field-wide milestones.

email:bonneau@nyu.edu

The Broyde Lab is focused on delineating the molecular mechanisms underlying the mutagenic and carcinogenic properties of certain environmental and endogenous carcinogens. We employ computer modeling, molecular mechanics and dynamics simulations and quantum mechanical calculations for structural and thermodynamic analyses, to connect structure and thermodynamics with biological function.

email: broyde@nyu.edu

Research in the Buccella group explores the interface of Inorganic Chemistry and Biology, focusing in the design and application of highly tailored systems for the recognition of metal ions and metalloenzymes, combined with careful manipulation of host-guest chemistry and cooperative effects in the assembly of metal complexes and supramolecular constructs for the selective binding of important biological targets. Emphasis is placed on exploring new avenues for elucidating the physiological and pathological roles of metal ions and metalloenzymes, and on developing new small-molecule diagnostic and therapeutic tools.

email:dbuccella@nyu.edu

Professor Jim Canary is the current chair of NYU's Chemistry Department. The Canary lab works in the areas of synthetic biomimetic and supramolecular chemistry with a focus on functional molecules that respond to a stimulus and therefore may function as sensors and actuators. In relation to chemical biology, we are interested in developing probes for metal ions and other species relevant to oxygen activation, and nanoscale bioconjugates.

email: james.canary@nyu.edu

The Carmona-Fontaine research group focuses on the role of metabolic alterations in the interaction between cancer cells and tumor associated stromal cells such as macrophages and T cells. We apply concepts from quantitative embryology, such as spatial patterning through cell communication and migration, to understand multi-cellular organization in tumors. To study these problems, we develop novel tissue-mimetic culture systems and we use high-throughput microscopy, image analysis, chemokine and metabolite measurements to understand the behavior of cancer cell populations and their response to stromal cells.

email:carlos.carmona-fontaine@nyu.edu

The Diao group focuses on solving long-standing problems in organic synthesis and sustainable energy research. We seek to provide strategically creative solutions through the development of transition metal catalysts. The rational design of catalysts is based on a thorough understanding of reaction mechanism. Driven by synthetic applications, we also synthesize and characterize new organometallic complexes with the goal of elucidating fundamental principles of molecular bonding.

email:diao@nyu.edu

The overarching goal of the Ghedin Laboratory's research is to understand how host-pathogen interactions impact the evolution, transmission, and pathogenesis of parasite infections. Through our research program, which meets at the interface of microbiology, genomics, systems biology, bioinformatics, and molecular parasitology/virology, we seek to identify the extent of intra- and inter-host microparasite (viruses and bacteria) diversity within the context of transmission and virulence, and parse the relationship between microbial ecology in the respiratory tract and disease progression.

email: ghedin@nyu.edu

The central goals of the Gresham laboratory are to understand adaptive evolution using and post-transcriptional gene expression regulation.  We aim to understand how cells regulate their growth and proliferation across a wide range of conditions and time scales and how gene expression is coordinated with cell growth. We study how cells optimize their proliferative capacity in the short term by remodeling gene expression and over long time scales through adaptive evolution. Our approach integrates genomics, evolutionary genetics, microbiology and computational biology. 

email: dgresham@nyu.edu

The Gunsalus Laboratory recognizes that a major challenge in systems biology is how to extract meaningful biological insights from large heterogeneous data sets that probe different aspects of gene function. Our laboratory uses high-throughput functional genomics and computational approaches to study the cell biology, post-translational regulation, and evolution of molecular mechanisms during early embryonic development in the simple animal model C. elegans and related nematodes. 

email: kcg1@nyu.edu

The principal research interest of the Hamilton group is in the field of molecular recognition and its application to problems in organic and biological chemistry. The Hamilton laboratory addresses these research questions with a variety of approaches utilizing a class of molecules termed 'foldamers', including: artificial receptor design, catalyst development, enzyme inhibition, peptidomimetic design, proteomimetic design, disruption of protein-protein interactions, and modulation of signal transduction. 

Research in the Hocky Group will focus on trying to determine the simple physical principles underlying complex biological phenomena. Past and ongoing work has focused on on understanding how interactions between many proteins at the molecular level give rise to cellular scale mechanical properties. We study how these structural elements combine with motor proteins and other active processes to drive cellular shape change, motion, and division. This work is done with computer modeling, while collaborating closely with experimental groups from Chemistry, Biology, and Physics.

email:hockyg@nyu.edu

The Kirshenbaum Laboratory is inspired by the beauty and complexity of nature’s biopolymers to develop new approaches in the design of macromolecules. We are creating new classes of macromolecules that integrate the desirable characteristics of biopolymers and synthetic polymers. Our goals are to find new avenues for the study of self-organization in macromolecules and to create innovative research tools for chemical biology, molecular pharmacology and materials science. Notable advances include the discovery of conformational ordering in N-substituted peptoid oligomers.
email: kent@nyu.edu

Research in the Koide group focuses on the design and engineering of protein recognition interfaces and applications of such "synthetic binding proteins" to biomedically important questions. We have been interested in understanding the molecular mechanisms of cellular signaling and regulation, particularly those controlled by protein-protein interaction, protein conformational change and post-translational modification and in developing novel "biologics" for controlling these processes.

email: shohei.koide@nyumc.org

The Kong lab currently focuses on the structure-based immunogen design for HIV/AIDS vaccine discovery. We are utilizing the strategy of the reverse-vaccinology by first understanding antibody antigen interactions of a panel of broadly cross-clade neutralizing human monoclonal antibodies (mAbs) through determination of atomic structures of these mAbs in complex with their cognate epitopes. We then create immunogens by grafting in 3D of suitable epitopes onto scaffold proteins.

email: xiangpeng.kong@med.nyu.edu

Research in the Lupoli Laboratory centers on studying pathways that are important for survival of bacterial pathogens under the stressful conditions that they encounter inside and outside of the host.  Using tools from biochemistry/chemical biology, chemistry, and microbiology (including sequencing-based approaches), we seek to discover the molecular players that modulate these pathways, and design molecules that can mimic or inhibit their functions.  With expertise in clinically-relevant bacteria, like Mycobacterium tuberculosis, we can answer fundamental questions that pertain to human infectious disease and the antibiotics used to treat these diseases.

The Mohammadi laboratory investigates the molecular mechanisms of fibroblast growth factor (FGF) signaling. We have been applying X-ray crystallography complemented with other contemporary biophysical and biochemical methods including Nuclear Magnetic Resonance (NMR) spectroscopy, Surface Plasmon Resonance (SPR) spectroscopy, Isothermal Titration Calorimetry (ITC), Multi-Angle Light Scattering (MALS) spectroscopy, mass spectrometry, steady-state kinase assay and cell-based assays to gain major mechanistic insights into the pleiotropic roles played by FGF signaling in human development, metabolism, and disease. Nearly all of the published structural data on FGF signaling stems from my laboratory, and hence my laboratory has become a world leader in the structural biology of FGF signaling.

email: moosa.mohammadi@nyumc.org

The Montclare Lab is performing groundbreaking research in engineering proteins to mimic nature and, in some cases, work better than nature. They work to customize artificial proteins with the aim of targeting human disorders, drug delivery and tissue regeneration as well as create nanomaterials for electronics. Using multidisciplinary expertise in chemistry and genetic engineering, these results have already been realized.

email: montclare@nyu.edu

Professor Benjamin Neel is the Director of the Perlmutter Cancer Institute within  the NYU School of Medicine. The major goal of the research carried out in the Neel laboratory is to elucidate the function and regulation of Ras signaling and to understand the biological output of normal and oncogenic Ras proteins. Our research focuses on the mechanistic framework underlying the physiologic and pathogenic roles of Ras proteins. Our work has led to discoveries regarding the involvement of the Ras oncogene in tumor immunity, cellular metabolism, and cell-to-cell signaling. We have experience with and access to the experimental tools that are necessary for in depth discovery and validation to address highly relevant questions existing in the areas of Ras signaling and cancer.

email:benjamin.neel@nyumc.org

The Nudler Laboratory investigates the basic mechanisms of transcription using various bacterial systems. We are particularly interested in the elaborate mechanics of the elongation phase of the transcription cycle. Using various biochemical and protein chemical tools developed in our lab over the years, we examine how RNA polymerase moves along its DNA template, how it responds to regulatory factors and signals encoded in RNA and DNA, and how it terminates transcription. We also study the interplay between transcription and other major cellular processes, such as translation, replication and repair of DNA.

email: evgeny.nudler@nyumc.org

My interests are in the understanding the role of intermediary metabolism in the development and progression of cancer through the advancement of small molecule inhibitors of metabolic enzymes and the creation of novel chemical techniques to study metabolic processes. We aim to develop and improve therapeutics that prevent the use of serine in treatment-refractory malignancies, either by blocking the synthesis of serine or by depleting this critical amino acid enzymatically or through dietary interventions. My lab has also become interested in the sources of serine in the tumor microenvironment and the role of serine in promoting mitochondrial function. 

email: michael.pacold@nyumc.org

The Pagano laboratory explores the roles that the ubiquitin system plays in fundamental cellular processes, such as cell growth, proliferation, and the DNA damage response. Our group is also committed to understanding how the deregulation of this regulatory network contributes to malignant transformation. 

email: michele.pagano@nyumc.org

The Schlick Laboratory is devoted to developing innovative

mathematical and computational tools for biomolecular modeling and simulation and applying them to fundamental biological problems involving protein/nucleic acid complexes associated with biological regulation. Such challenges include polymerase mechanisms, chromatin organization, and RNA structure and function.

email: schlick@nyu.edu

Work in the Seeman lab is concerned with the development of DNA Nanotechnology. Achievements include: Construction of a 3-D, 3-Connected DNA Object, a Cube. Designed Self-Assembly of a 2D Nucleic Acid Lattice, Construction of DNA Nanomechanical Devices, including a nano-scale assembly line, and, the key intermediate goals of self-assembling deliberate 3D DNA rhombohedral lattices with one or two molecules per asymmetric unit at 2.6 Å resolution. We are now prepared to put guests inside the rhombohedra and bring the deliberate self-assembled crystallization of macromolecules to fruition.

email: ned.seeman@nyu.edu

Research in the Traaseth laboratory is focused on revealing the molecular mechanisms of membrane transport proteins and the cellular signaling cascade mediated by receptor tyrosine kinases. The long-term goals of our research are to determine the microscopic changes occurring to the structure, dynamics, and function of proteins that underline pathologies affecting human health. In order to characterize these challenging systems, we primarily rely on nuclear magnetic resonance spectroscopy (solution and solid-state NMR).

email: traaseth@nyu.edu

The broader goal of the Trauner lab's research is the continuous refinement of chemical synthesis, its application towards the establishment of synthetic biological pathways, and its use in human precision medicine. Many of our target molecules are natural products or derivatives thereof, but we also investigate molecules that correspond to synthetic drugs or are designed from first principles. In terms of function, we are mostly interested in molecules that affect nervous systems, but we are also working on targets related to cancer, diabetes, and infectious diseases. We aim to make our synthetic molecules clinically relevant, either as diagnostic probes or as drugs.

email: dirktrauner@nyu.edu

The overarching goal of the Vogel Laboratory's research is to understand the dynamics of protein expression regulation in cells responding to environmental stress. To do so, we develop and use proteomics, computational modeling, andtargeted validation techniques to map changes in post-transcriptional regulation, translation, and protein stability in mammalian cells responding to a variety of environmental stimuli.

email: cvogel@nyu.edu

The Woerpel research group has been involved in the development of new methods for stereoselective synthesis. We developed new methods based upon the chemistry of organosilicon compounds, oxocarbenium ion intermediates, and organic peroxides. In the course of this work, we provided new stereochemical models and completed the synthesis of several natural products. We have prepared a family of cyclic peroxides that exhibit anti-malarial and anti-tumor activity, and we are exploring the origin of anti-cancer activity of these compounds in collaboration with Professor William Carroll (NYU Perlmutter Cancer Center), Professor Lara Mahal (NYU), and Professor Brent Stockwell (Columbia University). 

email: kwoerpel@nyu.edu

Research in the Zhang lab is established at the interface of computational chemistry and molecular biology, and has made significant advances ranging from developing innovative computational methods to provide new insights into medically important enzymes and biomolecular recognition. We are interested in developing and applying novel computational and theoretical methods to provide novel physical-chemical insights into important biological processes, and to facilitate the rational design of their modulators for probing important cellular pathways and for therapeutic use. Our specific research  interests are: Bridging ab initio Quantum Mechanics and Molecular Force Fields, Computational Enzymology, Inhibitor Designs to Target Protein-Protein Interactions, and Integrated Molecular Modeling and Data Analysis.

email: yingkai.zhang@nyu.edu