Climate and health, Ecology and evolution of infectious diseases, Infectious disease dynamics, Mathematical and computational biology, Theoretical ecology, Vector-borne and water-borne infections, Networks in ecology and evolution, Community ecology

Mercedes Pascual
Professor of Biology and Environmental Studies
Education
- 1997 Postdoctoral - Theoretical Ecology, Princeton University
- 1995 WHOI and MIT, PhD - Biological Oceanography
- 1989 New Mexico State University, M.Sc. - Mathematics
- 1985 Universidad de Ciencias Exactas y Naturales, Licenciatura - Biology
Mercedes Pascual is a Professor in the Departments of Biology and Environmental Studies at New York University, and an external faculty of the Santa Fe Institute. A theoretical and computational ecologist, she is interested in the population dynamics of infectious diseases, their response to changing environments and their interplay with pathogen diversity. Her research has combined process-based mathematical models with statistical inference methods for nonlinear and noisy systems, to address the impact of climate variability and climate change on the temporal and spatio-temporal patterns of water-borne and vector-borne infections. Her work has also addressed the interplay of transmission dynamics and pathogen evolution related to immune evasion. She is currently investigating these eco-evolutionary dynamics in hyper-diverse pathogens (of human, plant and microbial hosts) to understand coexistence of large numbers of strains and implications for population resilience. Finally, her work has contributed analyses of the structure of large interaction networks in ecology and epidemiology (describing “who eats whom”, “who infects whom”, “who is protected from whom”), and of the relationship between structure and stability in the face of environmental perturbations.
Dr. Pascual received her Ph.D. degree from the joint program of the Woods Hole Oceanographic Institution and the Massachusetts Institute of Technology. She was awarded a U.S. Department of Energy Alexander Hollaender Distinguished Postdoctoral Fellowship for studies at Princeton University, and a Centennial Fellowship in the area of Global and Complex Systems by the James S. McDonnell Foundation for her research at the University of Michigan. She received the Robert H. MacArthur award from the Ecological Society of America. She is a fellow of the American Association for the Advancement of Science and a member of the American Academy of Arts and Sciences.
Fellowships/Honors
- 2019 American Academy of Arts and Sciences
- 2015 Fellow of the Ecological Society of America
- 2014 Robert H. MacArthur Award of the Ecological Society of America
- 2008 Collegiate Professor, University of Michigan
- 2008 Howard Hughes Medical Investigator, University of Michigan
- 2004 Faculty Recognition Award, University of Michigan
- 2003 Discover Magazine: Top 50 Women in Science
- 2003 Fellow of the American Association for the Advancement of Science
- 1999 - 2008 James S. McDonnell Centennial Fellowship in Global and Complex Systems, University of Michigan
Ecology, Evolution and Environmental Biology
Selected Publications
De Roos A., Q. He and M. Pascual. An immune memory-structured SIS epidemiological model for hyper-diverse pathogens. Proceedings of the National Academy of Sciences USA, 2023 (in press)
Cazelles B., K. Cazelles, H. Tian, M. Chavez and M. Pascual, Disentangling local and global climate drivers in the population dynamics of mosquito-borne infections .Sci. Adv.9,eadf7202 (2023) DOI:10.1126/sciadv.adf7202
Dobson A.P., C. Ricci, R. Boucekkine, F. Gozzi, G. Fabbri, T. Loch-Temzelides, and M. Pascual. Balancing economic and epidemiological interventions in the early stages of pathogen emergence Science Advances .9, eade6169 2023 DOI:10.1126/sciadv.ade6169
Labbe F., Q. He, Q. Zhan, K.E. Tiedje, D.C. Argyropoulos, M.H. Tan, A. Ghansah, K.P. Day, and M.Pascual. Neutral vs. non-neutral genetic footprints of Plasmodium falciparum multiclonal infections PLoS Computational Biology 2023 01; 19(1):e1010816. PMID: 36595546
Romeo-Aznar V., L. Picinini Freitas, O. Goncalves Cruz, A.A. King, and M. Pascual. Fine-scale heterogeneity in population density predicts wave dynamics in dengue epidemics Nature Communications 2022 02 22; 13(1):996. PMID: 35194017
Santos-Vega M., P. Martinez, M.J. Bouma, V.J. Vaishnav, V. Kohli, V. Desai, and M. Pascual. The neglected role of relative humidity in the interannual variability of urban malaria in Indian cities Nature Communications 2022 13:533. PMID: 35087036
He Q., S. Pilosof, K.E. Tiedje, K.P. Day, and M. Pascual. Frequency-Dependent Competition Between Strains Imparts Persistence to Perturbations in a Model of Plasmodium falciparum Malaria Transmission. Frontiers in Ecology and Evolution 2021; 9.PMID: 35433714
M. Pascual and A. Baeza. What happens when forests fall? Elife. 2021 04 06; 10. PMID: 33821799
Rodo, X., P. Martinez, A. Siraj, M. Pascual. Malaria trends in Ethiopian highlands track the 2000 'slowdown' in global warming Nature Communications 2021 03 10; 12(1):1555. PMID: 33692343
Subramanian, R., Q. He and M. Pascual. Quantifying asymptomatic infection and transmission of COVID-19 in New York City using observed cases, serology, and testing capacity Proceedings of the National Academy of Sciences USA. 2021 03 02; 118(9). PMID: 33571106
Lowe, R., S. Lee, R. Martins Lana, C. Torres Codeco, M,C. Castro, M. Pascual. 2020. Emerging arboviruses in the urbanized Amazon rainforest. BMJ, Special Issue on Climate Change and Infectious Diseases 371:m4385.
Pilosof, S., S.A. Alcala-Corona, T. Wang, T. Kim, S. Maslov, R. Whitaker, M. Pascual. 2020. The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification Nature Ecology and Evolution, doi.org/10.1038/s41559-020-01312-z
Contact Information
Mercedes Pascual
Professor of Biology and Environmental Studies mp6774@nyu.edu Center for Genomics and Systems Biology12 Waverly Pl.
Room 305
New York, NY 10003
Phone: (212) 998-8250