Eugene Plavskin

Evolutionary constraints, evolution of gene regulatory networks

I am interested in how evolution rewires complex gene regulatory networks. My work focuses mainly on understanding how mutation space and regulatory network structure constrain this evolutionary process. To this end, I use a combination of high-throughput microscopy, sequencing, and modeling to understand mutational effects on fitness and other complex traits in yeast. I am also interested in developing new approaches to teaching evolutionary genetics and computational biology to undergraduates.

Plavskin, Y., de Biase, M. S., Schwarz, R. F., & Siegal, M. L. (2022). The rate of spontaneous mutations in yeast deficient for MutSβ function. bioRxiv, 2022.08.25.505291. https://doi.org/10.1101/2022.08.25.505291

Plavskin, Y., Li, S., Jung, H., Sartori, F. M., Buzby, C., Müller, H., Ziv, N., Levy, S.F., & Siegal, M. L. (2021). High-throughput microcolony growth analysis from suboptimal low-magnification micrographs. bioRxiv, 253724. https://doi.org/10.1101/253724

Sartori, F. M., Buzby, C., Plavskin, Y., & Siegal, M. L. (2021). High-throughput live imaging of microcolonies to measure heterogeneity in growth and gene expression. JoVE (Journal of Visualized Experiments), (170), e62038. https://doi.org/10.3791/62038

Plavskin, Y., Nagashima, A., Perroud, P. F., Hasebe, M., Quatrano, R. S., Atwal, G. S., & Timmermans, M. C. (2016). Ancient trans-acting siRNAs confer robustness and sensitivity onto the auxin response. Developmental Cell, 36(3), 276-289. https://doi.org/10.1016/j.devcel.2016.01.010

Plavskin, Y., & Timmermans, M. C. P. (2012, January). Small RNA-regulated networks and the evolution of novel structures in plants. In Cold Spring Harbor Symposia on Quantitative Biology (Vol. 77, pp. 221-233). Cold Spring Harbor Laboratory Press. https://doi.org/10.1101/sqb.2013.77.014878