Location: Silver 840 (Annex)
The TA Instrument Nano Differential Scanning Calorimeter (Nano-DSC) is designed to characterize the molecular stability of biomolecules in solution with very low concentration. The Nano-DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell.
This instrument uses the innovative capillary design attenuates the onset of sample aggregation until after unfolding is complete. The scanning temperature range is from -10 °C to 130 °C with a scan rates of 0.001 °C to 2 °C/min. The active cell volume is around 300 µL and the required sample volume is 450-600 µL.
The TA Instrument Nano-DSC Spectrometer was acquired through the support of New York University.