Analytical Spectrometers
Location: Silver 840 (Annex)
The TA Instrument Nano Differential Scanning Calorimeter (Nano-DSC) is designed to characterize the molecular stability of biomolecules in solution with very low concentration. The Nano-DSC obtains data using less sample than competitive designs. Solid-state thermoelectric elements are used to precisely control temperature and a built-in precision linear actuator maintains constant or controlled variable pressure in the cell.
This instrument uses the innovative capillary design attenuates the onset of sample aggregation until after unfolding is complete. The scanning temperature range is from -10 °C to 130 °C with a scan rates of 0.001 °C to 2 °C/min. The active cell volume is around 300 µL and the required sample volume is 450-600 µL.
The TA Instrument Nano-DSC Spectrometer was acquired through the support of New York University.
Location:Silver 840 (Annex)
The Nano ITC isothermal titration calorimeter is designed to provide maximum sensitivity and flexibility for the study of biomolecular binding. The instrument uses solid state thermoelectric heating and cooling systems to precisely control temperature and flexible injection syringe assemblies for efficient and accurate delivery of titrant. The true isothermal power compensation design of the Nano ITC instruments provides the highest sensitivity and flexibility for an ultrasensitive ITC analyzing biological samples in-solution.
The scanning temperature range is from 2 °C to 80 °C with a minimum detectable heat of 0.05 µJ and a maximum measureable heat of 5000 µJ. The active cell volume is around 190 µL and the minimum injection volume is 0.06 µL.
Location: Silver 717
The Malvern Zetasizer Nano series is the combinations of a particle size analyzer, zeta potential analyzer, molecular weight analyzer, protein mobility, and microrheology measurements. Particles and molecules from less than a nanometer in size to several microns can be analyzed by this instrument. This system is able to measure the following (1) size and microrheology using dynamic light scattering, (2) zeta potential and electrophoretic mobility using electrophoretic light scattering, and (3) molecular weight using static light scattering. In addition the system can be used in a flow configuration to connect to a GPC/SEC system for use as a chromatography size detector.