Thomas Theis, from North Carolina State University, will deliver a seminar entitled, "Parahydrogen Induced Polarization for Precision Measurements and Scalable Molecular Imaging." Hosted by Claudia Avalos.
For more information on Thomas Theis, click here.
Abstract: Parahydrogen induced polarization (PHIP) is cherished for its relative simplicity and ease. In this talk I will present recent progress with PHIP in hydrogenative addition and non-hydrogenative reversible exchange reactions to attain (a) Radiofrequency Amplification By Stimulated Emission of Radiation (RASER) for precision measurements of J-couplings and chemical shifts1–4 and (b) molecular imaging with cryogen-free, variable field MRI systems after SABRE-SHEATH hyperpolarization of 13C-pyruvate to above 10% polarization with a temperature cycling approach.5,6 Simultaneously, we continue the substrate scope expansion of our technology to many different metabolites, vitamins and drugs, including antifungals 7 and cancer fighting drugs.
1. Appelt, S. et al. SABRE and PHIP pumped RASER and the route to chaos. J. Magn. Reson. 322, 106815 (2021).
2. TomHon, P. M. et al. A Versatile Compact Parahydrogen Membrane Reactor. ChemPhysChem 22, 2526–2534 (2021).
3. Joalland, B. et al. Parahydrogen-Induced Radio Amplification by Stimulated Emission of Radiation. Angew. Chem. 59, 8654–8660 (2020).
4. Joalland, B., Theis, T., Appelt, S. & Chekmenev, E. Y. Background-Free Proton NMR Spectroscopy with Radiofrequency Amplification by Stimulated Emission Radiation. Angew. Chemie Int. Ed. 60, 26298–26302 (2021).
5. TomHon, P. et al. Temperature Cycling Enables Efficient SABRE-SHEATH and Imaging of 13C-Pyruvate. J. Am. Chem. Soc. 144, 282 (2022).
6. Adelabu, I. et al. Order-Unity 13C Nuclear Polarization of [1-13C]Pyruvate in Seconds and the Interplay of Water and SABRE Enhancement. ChemPhysChem 23, e202100839 (2022).
7. MacCulloch, K. et al. Hyperpolarization of common antifungal agents with SABRE. Magn. Reson. Chem. 59, 1225–1235 (2021).