Ruben Martin, from the Instiut Catala d'Investigacio Quimica (ICIQ), will deliver a virtual seminar entitled, "Ni-catalyzed functionalization of remote sp3 C–H bond." The host is Tianning Diao.
Zoom Link: https://nyu.zoom.us/j/97989771189?pwd=OUdLM3ltZkJSQ09hRkZwTlVmczF5dz09
For more information about Ruben Martin, click here.
Abstract: In recent years, chemists have been challenged to design new catalytic methodologies for converting (un)saturated hydrocarbons into value-added products by means of catalytic sp3 C-H functionalization. However, the ability to enable catalytic C-C bond-formation from a simple hydrocarbon is not particularly straightforward, as sp3 C-H bonds are less acidic and lack proximal empty low-energy or filled high-energy orbitals that interact with the d orbitals of the transition metal. Indeed, saturated hydrocarbons rank amongst the least reactive molecules, and their inertness is somewhat reflected by the forcing conditions that are required in the very few alkane transformations performed in industry, for example the cracking or reforming processes in oil refineries using heterogeneous catalysts operating at temperatures of approximately 400 to 600 ºC. Additionally, we should take into consideration site-selectivity principles due to the presence of multiple, yet similar, sp3 C-H bonds within the alkyl side chain. Recently, our group has developed a series of Ni-catalyzed reactions that enable the functionalization of remote sp3 C-H bonds in both saturated and unsaturated hydrocarbons via a formal dynamic displacement of the catalyst throughout the alkyl side-chain. These transformations are characterized by its simplicity, generality and modularity, thus increasing our ever-growing arsenal for converting simple precursors into added-value chemicals.