Paramjit Arora

Professor of Chemistry

Education

B.S. in Chemistry, University of Califonia at Berkeley

Ph.D. in Chemistry, University of California at Irvine

Postdoctoral research in Bioorganic Chemistry, California Institute of Technology

Areas of Research/Interest

Bioorganic Chemistry and Chemical Biology

Fellowships/Honors

American Peptide Society Makineni Lectureship (2015)

Eppley Visiting Professor of Oncology, University of Nebraska-Eppley Institute (2011)

Faculty Member, Faculty of 1000-Chemical Biology (2009)

Golden Dozen Award for Outstanding Teaching (2007)

U.S. delegate, First Joint Conference of American Chemical Society & Indian Council
of Scientific & Industrial Research (2006)

Inaugural American Chemical Society ORG Young Investigator Symposium Award (2006)

Whitehead Fellowship for Young Faculty in Biomedicine (2005)

Research Corporation Cottrell Scholar Award (2005)

NSF CAREER Award (declined) (2005)

Goddard Junior Faculty Fellowship (2005)

James D. Watson Investigator Award (2003)

American Cancer Society Postdoctoral Fellow (1999)

Selected Publications

Wuo, M. G.; Hong, S. H.; Singh, A.; Arora, P. S. Synthetic Control of Tertiary Helical Structures in Short Peptides. J. Am. Chem. Soc. 2018, 140, 16284-16290.

Sawyer, N.; Arora, P. S. Hydrogen Bond Surrogate Stabilization of  b-Hairpins. ACS   Chem. Biol. 2018, 13, 2027-2032.

Wuo, M. G.; Arora, P. S. Engineered protein scaffolds as leads for synthetic inhibitors of protein–protein interactions. Curr. Opin. Chem. Biol. 2018, 44, 16-22.

Rooklin, D.; Modell, A. E.; Li, H.; Berdan, V.; Arora, P. S.; Zhang, Y.  Targeting Unoccupied Surfaces on Protein–Protein Interfaces. J. Am. Chem. Soc. 2017, 139, 15560- 15563.

Wu, H.; Handoko; Raj, M.; Arora, P. S. Iterative Design of a Biomimetic Catalyst for  Amino Acid Thioester Condensation. Org. Lett. 2017, 19, 5122-5125.

Sawyer, N.; Watkins, A. M.; Arora, P. S. Protein Domain Mimics as Modulators of Protein–Protein Interactions. Acc. Chem. Res. 2017, 50, 1313-1322.

Ghosal, K.; Colby, J. M.; Das, D.; Joy, S. T.; Arora, P. S.; Krantz, B. A. Dynamic
Phenylalanine Clamp Interactions Define Single-Channel Polypeptide Translocation
through the Anthrax Toxin Protective Antigen Channel. J. Mol. Biol. 2017, 429, 900-910.

Watkins, A. M.; Bonneau, R.; Arora, P. S. In Modeling Peptide-Protein Interactions:
Methods and Protocols; Schueler-Furman, O., London, N., Eds.; Springer New York:
New York, NY, 2017, p 291-307.

Watkins, A. M.; Bonneau, R.; Arora, P. S. Side-Chain Conformational Preferences
Govern Protein–Protein Interactions. J. Am. Chem. Soc. 2016, 138, 10386-10389.
Modell, A. E.; Blosser, S. L.; Arora, P. S. Systematic Targeting of Protein-Protein
Interactions. Trends Pharm. Sci. 2016, 37, 702-713.

Joy, S. T.; Arora, P.S. An Optimal Hydrogen Bond Surrogate for α-Helices. Chem.
Commun. 2016, 52, 5738-5741.

Wuo, M. G.; Mahon, A. B.; Arora, P. S. An Effective Strategy for Stabilizing Minimal Coiled Coil Mimetics. J. Am. Chem. Soc. 2015, 137, 11618–11621.

Lao, B. B.; Drew, K.; Guarracino, D.; Brewer, T.; Heindel, D.; Bonneau, R.; Arora, P. S. “Rational Design of Topographical Helix Mimics as Potent Inhibitors of Protein-Protein Interactions.” J. Am. Chem. Soc. 2014, 136, 7877–7888.

Lao, B. B.; Grishagin, I.; Mesallati, H.; Brewer, T. F.; Olenyuk, B. Z.; Arora, P. S. “In vivo modulation of hypoxia-inducible signaling by topographical helix mimetics.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 7531–7536.

Miller, S. E.; Watkins, A. M.; Kallenbach, N. R.; Arora, P. S. “Effects of side chains in helix nucleation differ from helix propagation.” Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 6636-6641.

Kushal, S.; Lao, B. B.; Henchey, L. K.; Dubey, R. Mesallati, H.; Traaseth, N. J.; Olenyuk, B. Z.; Arora, P. S. “Protein Domain Mimetics as In Vivo Modulators of Hypoxia-Inducible Factor Signaling.” Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 15602-15607.

Patgiri, A.; Joy, S. T.; Arora, P. S. “Nucleation Effects in Peptide Foldamers.” J. Am. Chem. Soc. 2012, 134, 11495-11502.

Bullock, B. N.; Jochim, A. L.; Arora, P. S. “Assessing Helical Protein Interfaces for Inhibitor Design.” J. Am. Chem. Soc. 2011, 133, 14220-14223.

Patgiri, A.; Yadav, K.; Arora, P. S.; Bar-Sagi, D. “An Orthosteric Inhibitor of the Ras–Sos Interface.” Nature Chem. Biol. 2011, 7, 585-587.

Jochim, A. L.; Arora P. S. “Systematic Analysis of Helical Protein Interfaces Reveals Targets for Synthetic Inhibitors.” ACS Chem. Biol. 2010, 5, 919-923.