Keith Woerpel

NYU Global Research Institute Visiting Faculty Fellowship, NYU Florence (2016)

Golden Dozen Teaching Award, New York University (2015)

Chancellor’s Fellow, UCI (2010)

Outstanding Professor of the School of Physical Sciences, Selected by the Class of 2010, UCI (2010)

Campus Village Distinguished Professor Award, UCI (2010)

Outstanding Professor of the School of Physical Sciences, Selected by the Class of 2003, UCI (2003)

Johnson & Johnson Award for Research (2001)

Alfred P. Sloan Research Fellowship (2000)

AstraZeneca Excellence in Chemistry Award (1999)

Camille Dreyfus Teacher-Scholar Award (1998)

UCI Academic Senate Distinguished Assistant Professor for Teaching Award (1998)

Glaxo Wellcome Chemistry Scholar Award (1997)

Faculty Recognition Award from the Associated Students of UCI (1997)

Cottrell Scholar Award from the Research Corporation (1997)

UCI Academic Senate Distinguished Assistant Professor for Research Award (1997)

UCI Faculty Career Development Award (1997)

Presidential Early Career Award for Scientists and Engineers from the White House Office of Science and Technology Policy (1996)

American Cancer Society Junior Faculty Research Award (1996)

UCI Award for Excellence in Undergraduate Education (1996)

UCI School of Physical Sciences Outstanding Contributions to Undergraduate Education in Chemistry Award (1996)

National Institutes of Health Postdoctoral Research Fellow (1992-94)

Harvard Graduate School of Arts and Sciences Merit Fellow (1989-90)

Hugh Miller Spencer Scholarship Prize in Chemistry (1986)

Corning Glass Award for Excellence in Undergraduate Research (1986)

“Diastereoselectivities in Reductions of α-Alkoxy Ketones are not Always Correlated to Chelation-Induced Rate Acceleration.” N. D. Bartolo, A. L. Hornstein, A. Y. Zhao, K. A. Woerpel, Synthesis 2019, 51, 296-302.

“Mechanistic Insight into Additions of Allylic Grignard Reagents to Carbonyl Compounds.” N.D. Bartolo, K. A. Woerpel, J. Org. Chem. 2018, 83, 10197-10206.

“Cobalt-Catalyzed Oxygenation/Dearomatization of Furans.” J. P. Oswald, K. A. Woerpel, J. Org. Chem. 2018, 83, 9067-9075.

“FINO2 initiates ferroptosis through Gpx4 inactivation and driving lipid peroxidation.” M. M. Gaschler, A. A. Andia, H. Liu, J. M. Csuka, B. Hurlocker, C. A. Vaiana, D. W. Heindel, D. S. Zuckerman, P. H. Bos, E. Reznik, L. F. Ye, Y. Y. Tyurina, A. J. Lin, M. S. Shchepinov, A. Y. Chan,
E. Peguero-Pereira, M. A. Fomich, J. D. Daniels, A. V. Bekish, V. V. Shmanai, V. E. Kagan, L. K. Mahal, K. A. Woerpel, B. R. Stockwell, Nature Chem. Biol. 2018, 14, 507-515.

“Ferroptosis: a regulated cell death nexus linking metabolism, redox biology, and disease.” B. R. Stockwell, J. P. F. Angeli, H. Bayir, A. I. Bush, M. Conrad, S. Dixon, S. Fulda, S. Gascon, S. K. Hatzios, V. Kagan, K. Noel, J. Jiang, A. Linkermann, M. E. Murphy, M. Overholtzer, A. Oyagi, G.
Pagnussat, J. Park, C. Prives, Q. Ran, C. S. Rosenfeld, K. Salnikow, D. Tang, F. Torti, S. Torti, S.Toyokuni, K. A. Woerpel, D. D. Zhang, Cell 2017, 171, 273-285.

“Reactions of Allylmagnesium Halides with Carbonyl Compounds: Reactivity, Structure, and Mechanism.” N. D. Bartolo, J. A. Read, E. M. Valentín, K. A. Woerpel, Synthesis 2017, 49, 3237- 3246.

“Reactivity of Seven-Membered-Ring trans-Alkenes with Electrophiles.” J. R. Sanzone, K. A. Woerpel, Synlett 2017, 28, 2478-2482.

“Uncatalyzed Carboboration of Seven-Membered-Ring trans-Alkenes: Formation of Air-Stable Trialkylboranes.” J. R. Sanzone, C. Hu, K. A. Woerpel, J. Am Chem. Soc. 2017, 139, 8404-8407.

“Additions of Organomagnesium Halides to a-Alkoxy Ketones: Revision of the Chelation-Control Model.” J. A. Read, Y. Yang, K. A. Woerpel, Org. Lett. 2017, 19, 3346-3349.

“Diastereoselective Silylene Transfer Reactions to Chiral Enantiopure Alkenes: Effects of Ligand Size and Substrate Bias.” C. Z. Rotsides, K. A. Woerpel, Dalton Trans. 2017, 46, 8763-8768.

“Allylmagnesium Halides Do Not React Chemoselectively Because Reaction Rates Approach the Diffusion Limit.” J. A. Read, K. A. Woerpel, J. Org. Chem. 2017, 82, 2300-2305.

“Insertion Reactions of Silacyclopropanes: Evidence for a Radical-Based Mechanism.” C. Z.Rotsides, K. A. Woerpel, Organometallics 2016, 35, 3132-3138.

“[4+2] Cycloadditions of Seven-Membered-Ring trans-Alkenes: Decreasing Reactivity with Increasing Substitution of the Seven-Membered Ring.” J. Santucci III, J. R. Sanzone, K. A. Woerpel, Eur. J. Org. Chem. 2016, 2933-2943.

“Cu(I)-Catalyzed Hydroperoxidation of Enynes Using Molecular Oxygen and Hydroxylamines:Synthesis of Propargyl Hydroperoxides.” M. R. Miner, K. A. Woerpel, Eur. J. Org. Chem. 2016, 1860-1866.

“Five-Membered Ring Peroxide Selectively Initiates Ferroptosis in Cancer Cells.” R. P. Abrams, W. L. Carroll, K. A. Woerpel, ACS Chem. Biol. 2016, 11, 1305-1312.

“Stereoelectronic Model to Explain Highly Stereoselective Reactions of Seven-membered Ring Oxocarbenium Ion Intermediates.” M. G. Beaver, T. M. Buscagan, O. Lavinda, K. A. Woerpel, Angew. Chem. Int. Ed. 2016, 55, 1816-1819.

“High Reactivity of Seven-Membered-Ring trans-Alkenes.” J. R. Sanzone, K. A. Woerpel, Angew. Chem. Int. Ed. 2016, 55, 790-793.

“Evidence That Additions of Grignard Reagents to Aliphatic Aldehydes Do Not Involve Single-Electron Transfer Processes.” D. A. L. Otte, K. A. Woerpel, Org. Lett. 2015, 17, 3906-3909.

“Participation by Alkoxy Groups in Reactions of Acetals: Violation of the Reactivity-Selectivity Principle in a Curtin–Hammett Kinetic Scenario.” A. Garcia, J. R. Sanzone, K. A. Woerpel, Angew. Chem. Int. Ed. 2015, 54, 12087-12090.

“An SN1-type Reaction to Form the 1,2-Dioxepane Ring: The Synthesis of 10,12-Peroxycalamenene.” J. A. Hilf, L. W. Witthoft, K. A. Woerpel, J. Org. Chem. 2015, 80, 8262-8267.

“Copper(I)-Catalyzed Oxidation of Alkenes Using Molecular Oxygen and Hydroxylamines:Synthesis and Reactivity of a-Oxygenated Ketones.” A. A. Andia, M. R. Miner, K. A. Woerpel, Org.Lett. 2015, 17, 2704-2707.

“Influence of Alkoxy Groups on Rates of Acetal Hydrolysis and Tosylate Solvolysis:Electrostatic Stabilization of Developing Oxocarbenium Ion Intermediates and Neighboring-Group Participation to Form Oxonium Ions.” A. Garcia, D. A. L. Otte, W. A. Salamant, J. R. Sanzone, K. A. Woerpel, J. Org. Chem. 2015, 80, 4470-4480.

“Structure and Reactivity of an Isolable Seven-Membered Ring trans-Alkene.” B. Hurlocker, C. Hu, K. A. Woerpel, Angew. Chem. Int. Ed. 2015, 54, 4295-4298.

“Acceleration of Acetal Hydrolysis by Remote Alkoxy Groups: Evidence for Electrostatic Effects on the Formation of Oxocarbenium Ions.” A. Garcia, D. A. L. Otte, W. A. Salamant, J. R. Sanzone, K. A. Woerpel, Angew. Chem. Int. Ed. 2015, 54, 3061-3064.

“Formation of an Endoperoxide upon Chromium-catalyzed Allylic Oxidation of a Triterpene by Oxygen.” A. Chung, M. R. Miner, K. J. Richert, C. J. Rieder, K. A. Woerpel, J. Org. Chem. 2015, 80, 266-273.

“Synthesis of Silyl Monoperoxyketals by Regioselective Cobalt-Catalyzed Peroxidation of Silyl Enol Ethers: Application to the Synthesis of 1,2-Dioxolanes.” B. Hurlocker, M. R. Miner, K. A. Woerpel, Org. Lett. 2014, 16, 4280-4283.

“Effect of Conformational Rigidity on the Stereoselectivity of Nucleophilic Additions to Fivemembered Ring Bicyclic Oxocarbenium Ion Intermediates.” O. Lavinda, V. T. Tran, K. A. Woerpel, Org. Biomol. Chem. 2014, 12, 7083-7091.

“Solvent Effects in the Nucleophilic Substitutions of Tetrahydropyran Acetals Promoted by Trimethylsilyl Trifluoromethanesulfonate: Trichloroethylene as Solvent for Stereoselective C- and OGlycosylations.” J. C. Kendale, E. M. Valentín, K. A. Woerpel, Org. Lett. 2014, 16, 3684-3687.

“Synthesis and Reactivity of 1,2-Dioxolanes from b,g-Epoxy Ketones.” W. V. Kandur, K. J. Richert, C. J. Rieder, A. M. Thomas, C. Hu, J. W. Ziller, K. A. Woerpel, Org. Lett. 2014, 16, 2650-2653.

“13C NMR Spectroscopy for the Quantitative Determination of Compound Ratios and Polymer End-Groups.” D. A. L. Otte, D. E. Borchmann, C. Lin, M. Weck, K. A. Woerpel, Org. Lett. 2014, 16, 1656-1659.

“Diastereoselective Synthesis of Eight-Membered Ring Allenes from Propargylic Epoxides and Aldehydes by Silylene Insertion into Carbon–Oxygen Bonds.” C. Z. Rotsides, C. Hu, K. A. Woerpel, Angew. Chem. Int. Ed. 2013, 52, 13033-13036.

“Nucleophilic Addition to Silyl-Protected Five-Membered Ring Oxocarbenium Ions Governed by Stereoelectronic Effects.” V. T. Tran, K. A. Woerpel, J. Org. Chem. 2013, 78, 6609-6621.

“Diastereoselective Synthesis of Seven-Membered Ring trans-Alkenes from Dienes and Aldehydes by Silylene Transfer.” M. A. Greene, M. Prévost, J. Tolopilo, K. A. Woerpel J. Am. Chem. Soc. 2012, 134, 12482-12484.

“Synthesis of Silyloxy Dienes by Silylene Transfer to Divinyl Ketones: Application to the Asymmetric Synthesis of Substituted Cyclohexanes.” C. C. Ventocilla, K. A. Woerpel, J. Org. Chem. 2012, 77, 3277-3283.

“Spectroscopic and X-ray Crystallographic Evidence for Electrostatic Effects in 4-Substituted Cyclohexanone-Derived Hydrazones, Imines, and Corresponding Salts.” D. J. Dibble, J. W. Ziller, K.A. Woerpel J. Org. Chem. 2011, 76, 7706-7719.

“Silylene-mediated Polarity Reversal of Dienoates: Additions of Dienoates to Aldehydes at the g-Position to form trans-Dioxasilacyclononenes.” C. C. Ventocilla, K. A. Woerpel J. Am. Chem. Soc. 2011, 133, 406-408.