Daniela Buccella

Professor of Chemistry; Associate Chair

Education

Ph.D. Chemistry, Columbia University

M.A. Chemistry, Columbia University

B.S. Chemistry, Summa Cum Laude, Universidad Simón Bolívar, Caracas, Venezuela

Areas of Research/Interest

Bioinorganic Chemistry, Chemical Biology, Molecular Imaging

Fellowships/Honors

National Science Foundation CAREER Award (2015)

Whitehead Fellowship for Junior Faculty in Biomedical and Biological Sciences (2012)

National Institutes of Health NSRA Ruth Kirschstein Postdoctoral Fellowship (2009-present)

Louis Hammett Award to outstanding Ph.D. student, Columbia University (2008)

Edith and Eugene Blout Scholarship (2005-2006)

Jack Miller Award to outstanding teaching assistant, Columbia University (2005)

Best Student Award, Universidad Simón Bolívar (2001).

Publications

Lin, Q.; Buccella, D. “Highly Selective, Red Emitting BODIPY-Based Fluorescent Indicators for Intracellular Mg2+ Imaging”. J. Mater. Chem. B 2018, 6, 7247.

Rooker, D. R.; Klyubka, Y.; Gautam, R.; Tomat, E.; Buccella, D. “Peptide-Based Fluorescent Probes for Deacetylase and Decrotonylase Activity: Toward a General Platform for Real-Time Detection of Lysine Deacylation”. ChemBioChem. 2018, 19, 496.

Zhang, G; Jacquemin, D.; Buccella, D. “Tuning the Spectroscopic Properties of Ratiometric Fluorescent Metal Indicators: Experimental and Computational Studies on Mag-fura-2 and Analogues” J. Phys. Chem. B 2017, 121(4), 696.

Lin, Q; Gruskos, J. J.; Buccella, D. “Bright, Red-Emitting Fluorescent Sensor for Intracellular Imaging of Mg2+” Org. Biomol. Chem. 2016, 14, 11381.

Gruskos, J. J.; Zhang, G.; Buccella, D. “Visualizing Compartmentalized Magnesium on Demand with Small Molecule Fluorescent Sensors” J. Am. Chem. Soc. 2016, 138(44), 14639.

Brady, M.; Piombo, S. D.; Hu, C.; Buccella, D. “Spectroscopic and Structural Insight into Metal Binding of o-Aminophenol-N,N,O-Triacetic Acid (APTRA) Chelators: Implications for Design of Metal Indicators” Dalton Trans. 2016, 45, 12458.

Zhang, G.; Gruskos, J. J.; Afzal, M. S.; Buccella, D. “Visualizing Changes in Mitochondrial Mg2+ During Apoptosis with Organelle-Targeted Triazole-Based Ratiometric Fluorescent Sensors” Chem. Sci. 2015, 6, 6841.

Rooker, D. R.; Buccella, D. “Real-Time Detection of Histone Deacetylase Activity with a Small Molecule Fluorescent and Spectrophotometric Probe”. Chem. Sci. 2015, 6, 6456.

Afzal, M. S.; Pitteloud, J.-P.; Buccella, D. “Enhanced Ratiometric Fluorescent Indicators for Magnesium Based on Azoles of the Heavier Chalcogens”. Chem. Commun. 2014, 50, 11358.

Schwartz, S. C.; Pinto, B.; Pitteloud, J.-P.; Buccella, D. “Formation of Ternary Complexes with MgATP: Effects on the Detection of Mg2+ in Biological Samples by Bidentate Fluorescent Sensors”. Inorg. Chem.2014, 53(6), 3204.

Lin, W.; Buccella, D.; Lippard, S. J. “Visualization of Peroxynitrite-Induced Changes of Labile Zn2+ in Endoplasmic Reticulum with Benzoresorufin-based Fluorescent Probes”. J. Am. Chem. Soc. 2013, 135(36),13512.

Apfel, U.-P.; Buccella, D.; Wilson, J. J.; Lippard, S. J. “Detection of Nitric Oxide and Nitroxyl with Benzoresorufin-Based Fluorescent Sensors”. Inorg. Chem. 2013, 52(6), 3285.

Buccella, D.; Horowitz, J. A.; Lippard, S. J. “Understanding Zinc Quantification with Existing and Advanced Ditopic Fluorescent Zinpyr Sensors” J. Am. Chem. Soc. 2011, in press.

Carnes, M.; Buccella, D.; Chen, J. Y.-C.; Ramirez, A. P.; Turro, N. J.; Nuckolls, C.; Steigerwald, M. “A Stable Tetraalkyl Complex of Nickel(IV)” Angew. Chem., Intl. Ed. 2009, 48(2), 290-294.

Buccella, D.; Parkin, G. “p-tert-Butyltetrathiatetramercaptocalix[4]arene as a Sulfur-Rich Platform for Molybdenum, Tungsten and Nickel” Chem. Commun. 2009, 289-291.

Buccella, D.; Janak, K. E.; Parkin, G. “Reactivity of Mo(PMe3)6 towards Benzothiophene and Selenophenes: New Pathways Relevant to Hydrodesulfurization”. J. Am. Chem. Soc. 2008, 130(48), 16187-16189.

Buccella, D.; Parkin, G. “Mononuclear and Dinuclear Molybdenum and Tungsten Complexes of p-tert-Butyltetrathiacalix[4]arene and p-tert-Butyltetrasulfonylcalix[4]arene: Facile Cleavage of the Calixarene Ligand Framework by Nickel” J. Am. Chem. Soc. 2008, 130(27), 8617-8619.

Melnick, J. G.; Yurkerwich, K.; Buccella, D.; Sattler, W.; Parkin, G. “Molecular Structures of Thimerosal (Merthiolate) and Other Arylthiolate Mercury Alkyl Compounds” Inorg. Chem. 2008, 47(14), 6421-6426.