Vladimir Shafirovich

Research Professor of Chemistry
M.S., Moscow State University; Ph.D., Institute of Chemical Physics, Chernogolovka; D. Sc., Institute of Chemical Physics, Chernogolovka

Email:

Research Interests:

Biophysical Chemistry: kinetic laser spectroscopy studies of oxidative DNA damage induced by reactive oxygen and nitrogen species; biological impact of oxidatively modified DNA bases; chemistry of nitroxyl and its anion in aqueous solutions

Selected Works:

Lymar, S. V., Shafirovich, V. Photoinduced Release of Nitroxyl and Nitric Oxide from Diazeniumdiolates. J. Phys. Chem. B 111, 6861-6867 (2007).

Yun, B. H., Lee, Y. A., Kim, S. K., Kuzmin, V., Kolbanovskiy, A., Dedon, P. C., Geacintov, N. E., Shafirovich, V. Photosensitized Oxidative DNA Damage: from Hole Injection to Chemical Product Formation and Strand cleavage. J. Am. Chem. Soc. 129, 9321-9332 (2007).

Lewis, F. D., Zhu, H., Daublain, P., Fiebig, T., Raytchev, M., Wang, Q., Shafirovich, V. Crossover from Superexchange to Hopping as the Mechanism for Photoinduced Charge Transfer in DNA Hairpin Conjugates. J. Am. Chem. Soc. 128, 791-800 (2006).

Crean, C., Geacintov, N. E., Shafirovich, V. Oxidation of Guanine and 8-Oxo-7,8-Dihydroguanine by Carbonate Radical Anions: Insight from Oxygen-18 Labeling Experiments. Angew. Chem., Int. Ed. Engl., 44, 5057-5060 (2005).

Misiaszek, R., Crean, C., Geacintov, N. E., Shafirovich, V. Combination of Nitrogen Dioxide Radicals with 8-Oxo-7,8-dihydroguanine and Guanine Radicals in DNA: Oxidation and Nitration End-Products. J. Am. Chem. Soc. 127, 2191-2200 (2005).

Misiaszek, R., Uvaydov, Y., Crean, C., Geacintov, N. E., Shafirovich, V. Combination Reactions of Superoxide with 8-Oxo-7,8-Dihydroguanine Radicals in DNA: Kinetics and End-Products. J. Biol. Chem. 280, 6293-6300 (2005).

Misiaszek, R., Crean, C., Joffe, A., Geacintov, N. E., Shafirovich, V. Oxidative DNA Damage Associated with Combination of Guanine and Superoxide Radicals and Repair Mechanisms via Radical Trapping. J. Biol. Chem. 279, 32106-32115 (2004).

Shafirovich, V., Lymar, S. V. Spin-Forbidden Deprotonation of Aqueous Nitroxyl (HNO). J. Am. Chem. Soc. 125, 6547-6552 (2003).

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