Molecular and cellular biology laboratories pursue advanced research aimed at understanding fundamental cellular processes including ones implicated in health and disease. Research topics include cell programming, cellular morphogenesis and circadian rhythms, as well as chromatin biology and epigenetics, protein translation and degradation, drug resistance and carcinogenesis. These issues are being addressed in diverse systems, including mammalian cell culture, bacteria, yeasts, social amoeba, parasitic protozoa, worms and fruit flies. Studies exploit techniques ranging from molecular genetics and biochemistry to genomics, digital imaging, mathematical and structural modeling. Researchers work in cutting-edge research facilities and share access to several core services, including the Sequencing (GenCore) Facility (high-throughput sequencing and expression analysis) and an Imaging Core (with confocal and other state-of-the-art microscopes).
Molecular & Cellular Biology
- Justin Blau
Molecular, cellular and neuronal mechanisms underlying the circadian clock. - Richard Bonneau
Genome scale interrogation and modeling of transcription, signalling, and chromatin networks. - Suse Broyde
DNA damage and repair, mutagenesis, and carcinogenesis. - Jane Carlton
Molecular genetic mechanisms of drug resistance and charact. of malaria and trichomonads. - Patrick Eichenberger
Regulation of protein localization in spore forming bacteria. - Sevinc Ercan
Genome-wide distribution of proteins. - David Fitch
Cellular morphogenesis of nematode male tails. - Andreas Hochwagen
Meiotic chromosome structure, recombination and checkpoints.
- Fei Li
Molecular mechanisms of epigenetics and chromatin regulation. - Esteban Mazzoni
Molecular logic of cell programming transcription factors. - Alexander Mogilner
Mechanics of cell motility and mitosis; galvanotaxis. - Neville Sanjana
Bioengineering, Genomics, Neuroscience, Cancer Biology, Systems Biology
- David Scicchitano
Interaction of mammalian RNA polymerases with damaged sites in expressed genes. - Duncan Smith
DNA replication and repair; Epigenetics. - Christine Vogel
Roles and functions of RNA-binding proteins and other translation regulators.