Center For Genomics & Systems Biology Faculty

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Kenneth D. Birnbaum

Associate Professor of Biology; Faculty Director of the Cellular Analysis Core; Director, PhD Program

Research Interests: Developmental and evolutionary genomics of plants. The origin and genetic programming of cell types.

Our research focuses on the role of stem cells and cellular plasticity in the plant's high capacity for regeneration. We use live imaging and global analysis of specific cell types to model the dynamics of tissue repair in high resolution during organ regeneration.

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Richard A. Bonneau

Professor of Biology and Computer Science; Faculty Director of Bioinformatics

Research Interests: Systems Biology and Protein Modeling

Our goal is to develop and apply state-of-the art methods to infer genomic networks, integrating computational approaches with multiple integrated data types (RNA expression, proteomics, metabolomics and genome structure). My group is also working on protein folding prediction, to assist functional studies through examining protein structure/function relationships.

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Jane Carlton

Professor of Biology; Director, Center for Genomics and Systems 

Research Interests: Comparative genomics of eukaryotic microbes (protists); genomics and global public health.

The Carlton lab uses the tools of comparative genomics (bioinformatics, genomics, molecular evolution, and population genetics) to compare the genomes of related species of protist, including the malaria parasite Plasmodium, and species of trichomonad such as the sexually-transmitted pathogen Trichomonas vaginalis. Our ultimate goal is to reveal the biological mechanisms that parasites use to interact with their hosts, and identify characteristics that can be exploited to develop better methods of control, e.g. drugs, vaccines, diagnostics and surveillance tools.

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Carlos Carmona-Fontaine

Assistant Professor of Biology

Research Interests: Multicellular organization in health and disease. Cell biology. Cancer and developmental biology. Social behaviors in cells.

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Gloria M. Coruzzi

Carroll and Milton Petrie Professor; Professor of Biology

Research Interests: Plant Systems Biology and Evolutionary Genomics

Our research in Plant Systems Biology aims to predictively model and manipulate gene regulatory networks affecting nitrogen-regulation of metabolism and root development exploiting the genomes of Arabidopsis and its natural variants. We have also developed phylogenomic approaches to identify genes associated with the evolution of key plant traits such as seeds.

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Patrick Eichenberger

Associate Professor of Biology

Research Interests: Comparative and functional genomics of endospore-forming bacteria.

Our lab uses microbial genomics-based approaches to study the transcriptional regulatory network of the spore-forming bacterium Bacillus subtilis. We are also investigating the mechanisms of assembly of the spore coat, the multi-layered envelope of Bacillus spores.

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Sevinc Ercan

Associate Professor of Biology

Research Interests: Developmental Genomics, Epigenetics, Chromatin

Our goal is to understand how chromatin regulates gene expression during development. In particular, we study the regulation of X chromosome transcription in C. elegans.

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Elodie Ghedin

Professor of Biology and Global Public Health; Faculty Director of Genomic Sequencing

Research Interests: Evolutionary genomics of infectious agents; neglected tropical diseases; microbiome and virus metagenomic studies.

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David J. J. Gresham

Associate Professor of Biology; Faculty Director of Bioinformatics

Research Interests: Genomics of adaptive evolution, growth-rate regulation and post-transcriptional gene regulation.

What are the genetic networks that regulate cell growth and quiescence? What regulates the post-transcriptional fate of messenger RNA?

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Kris Gunsalus

Associate Professor of Biology

Research Interests: Developmental systems biology.

Our laboratory is interested in the integrative analysis of diverse functional genomics data to identify groups of genes that work in specific cellular and developmental processes. We use integrative approaches to analyze and interpret large-scale datasets and to generate testable hypotheses on gene function in different biological systems, including C. elegans and mouse early embryogenesis.

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Edo Kussell

Associate Professor of Biology and Physics

Research Interests: Computational biology, evolution, and biological physics

We work on problems at the interface of biology and physics, with emphasis on populations, evolution, and stochastic dynamics. We combine theoretical biophysical approaches with experiments and bioinformatics to explore systems that exhibit complex, population-level phenomena.

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Fabio Piano

Professor of Biology; Provost, NYU Abu Dhabi; Founding Director, Center for Genomics and Systems Biology

Research Interests: Genomics, genetics and evolution of early C. elegans development.

We study the genetic and evolutionary mechanisms underlying early embryonic development using a combination of molecular genetic and functional genomics approaches in the animal model C. elegans and related nematodes.

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Michael Purugganan

Silver Professor; Professor of Biology; Dean for Science

Research Interests: Plant Evolutionary Genomics

We study the evolutionary and ecological genomics of adaptation and species diversification. We focus most of our work on plants (including Arabidopsis and domesticated crops such as rice), although we also investigate other systems, including social evolution in Dictysotelium. Our approach is to integrate perspectives from a wide range of disciplines, including population genomics, systems biology, developmental genetics, landscape ecology, and even archaeology.

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Matthew Rockman

Associate Professor of Biology

Research Interests: Evolutionary and molecular causes of heritable variation in animals

Our goal is to understand the relationship between the molecular mechanisms that shape phenotypes within individuals and the evolutionary mechanisms that generate and maintain phenotypic variation within populations. This project requires that we identify the functional allelic variants that segregate in nature, understand their molecular mechanisms, characterize their population genetic dynamics, and build models that explain these dynamics in terms of molecular biology and ecology.

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Neville Sanjana

Assistant Professor of Biology

Research Interests: Bioengineering, Genomics, Neuroscience, Cancer Biology, Systems Biology

Our lab develops technologies to understand how human genetic variants cause diseases of the nervous system and cancer. We use a multi-disciplinary approach, combining genome engineering, pooled genetic screens, bioinformatics, electrophysiology, and imaging, to dissect the inner workings of the human genome and its dysfunction in autism and tumor evolution.

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Rahul Satija

Assistant Professor of Biology

Research Interests: Single cell genomics, transcriptional regulation, computational biology

Our goal is to understand how cellular heterogeneity encodes the molecular structure, function, and regulation of complex biological systems. We combine single cell genomics with tailored computational methods to study how cells work together to drive biological processes and behaviors.

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Mark L. Siegal

Associate Professor of Biology; Director, Undergraduate Studies

Research Interests: evolutionary systems biology; robustness and evolution of complex traits

Our aim is to understand the evolution of complex traits, by studying the gene-regulatory networks that underlie them. Our work uses two major model organisms (flies and yeast) as well as computational analyses.

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Duncan Smith

Assistant Professor of Biology

Research Interests: Mechanisms and regulation of DNA replication; epigenetics; RNA processing

My lab uses genomics-based approaches to investigate DNA replication: we are particularly interested in how the various enzymatic activities required for lagging- strand synthesis are regulated and coordinated to ensure universally faithful replication in the face of genomic diversity.

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Christine Vogel

Associate Professor of Biology

Research Interests: mass spectrometry, quantitative proteomics, dynamical systems, translation regulation, stress response, protein evolution

My research revolves around proteins, their properties, evolution, and expression patterns. I am a systems biologist who uses statistical and computational tools, large-scale quantitative mass spectrometry, and molecular biology techniques to study the dynamics of the cellular proteome.